Syllabus
1.Syndromology and symptomatology ? introduction. 2.Making a diagnosis. 3.Amelogenesis imperfecta, dentinogenesis imperfecta and osteogenesis imperfecta ? syndromology and symptomatology. 4.Families with multiple idiopathic impactions of teeth. 5.Hajdu ? Cheney syndrome. 6.Prenatal diagnosis , syndromology and symptomatology, amniocentesis, ultrasonography, fetal echocardiography, radiographic techniques. 7.Pachydermoperiostosis. 8.Congenital spine deformities and rare orofacial syndromology. 9.Some bone and teeth dysplasias ? bone and dental tissues, oligodontia, hypodontia and anodontia, hereditary disorders and genetic prevention, and their diagnosis, mirror foot as part of syndromology, cleidocranial dysplasia and low density of bones, biomechanics, clinical picture, genetic trait of inheritance, mucopolysaccharidoses and oligosaccharidoses, multiple cartilaginous exostoses, enchondromatoses and enchondromatoses with vertebral involvement, comparative syndromology, material and biomechanical properties, osteopetrosis and pycnodysostosis with high density of bones, EMG syndrom, Parkes ? Weber ? Klippel ? Trenaunay syndrom, hemihypertrophy and asymmetry, genetic consultation. 10.Goldenhar syndrome and related defects: Abnormal vertebral segmentation: Klippel ? Feil anomalad , spondylothoracal dysplasia Jarcho - |Levin, facioauriculovertebral spectrum include hemifacial microsomia, VACTERL, VATER, neural tube dects (NTD), anencephaly, encephalocele, Poland ? Moebius syndrom. 11.Revmatology and genetics, osteoartropathy, biology and biomechanics. 12.Hematology and genetics. 13.Basal cell nevus syndrome ? diagnostics and genetics approaches. 14.Arthrogryposis multiplex congenita. 15.Duchenne myopathy and prenatal diagnostic. 16.Pierre ? Robin anomalad. 17.Cerebrocostomandibular syndrome. 18.Syndromology of situs viscerum inversus.
Annotation
In this subject the students will become acquainted with selected basic genetic principles in dentistry. Genealogy, types of inheritance, monogenic conditioned signs.
Multifactorial inheritance. Structure and function of chromosomes, caryotype.
Numerical and structural aberration. Mutation, mutagens, molecular basis of genetic diseases.
Teratogenesis, inborn developmental defects. Basics of oncogenesis. Genetic counselling. Basics of genealogical examination.
Principles of genetic counselling in manifestations of hereditary diseases and syndromes in orofacial area.