Syllabus
Lectures
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Introduction. History of pathophysiology. Health and disease. Organ, cellular and molecular level of etiopathogenesis of the disease.
Haematopoiesis and its regulation, failure of haematopoiesis, leukemogenesis
Anemias I
Anemias II and polycythemias.
Myeloproliferative disease: CML, AML, myelodysplastic syndromes
Lymphoproliferative disease: lymphomas, CLL, plasmocytoma and amyloidosis
Immunohematology, pathophysiological aspects of blood transfusion, stem cell and bone marrow transplantation
DISORDER OF CIRCULATORY SYSTEM. Disorders of blood pressure, their causes and consequences
Role of physiological regulation in pathophysiology of cardiovascular disease and in general
Heart insufficiency and heart failure.
Congenital heart disease and valvular disease.
Kardiomyopathies; Atherosclerosis.
Ischemic heart disease, angina, myocardial infarction.
Arrhytmias.
DISORDERS OF THE RESPIRATORY SYSTEM. Respiratory insuficiency, ARDS.
Disturbances of ventilation mechanics - obstruction and restriction lung disease. Lung fibrosis.
Pathogenesis of asthma and COPD.
Disorders of ventilation perfusion matching in lungs.
Hypoxia. Pathophysiological basis of oxygenotherapy.
Disorders of the acid-base chemistry, influence of respiration, lungs and altered metabolism
RENAL DISEASE. Tubular and glomerular disorders.
Acute renal failure
Chronic renal insufficiency and failure.
Nephritic and nephrotic syndrome. Tubular disorders.
Disturbances of water and mineral balance. Edemas.
DISORDERS OF THE GASTROINTESTINAL SYSTEM. Oral cavity and oesophagus, dysphagias, gastroesophageal reflux
Disorders of the gastric secretion and function, gastroesophageal reflux
Malabsorption syndromes, disorders of small and large intestines.
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Seminars:
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Introduction, organisational information, (diagnostic methods in hematology)
Diagnostic approaches in hematology - pathophysiological aspects
Examination of blood clotting - pathophysiological aspects block seminar I (A, B or C)
Diagnostic approaches in cardiology I - haemodynamics
Diagnostic approaches in cardiology II - ECG
Diagnostic approaches in cardiology III - arrhythmias
Pathophysiological interpretion of ECG curves and case studies
Diagnostic approaches in respiratory disease
Diagnostic approaches in renal disease - pathophysiological aspects
Examination of the internal environment - water and ions block seminar III (A, B or C)
Credit, presentation animal models in pathophysiology/ excurtion of interested students
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Special seminars:
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Block I - Blood disorders
Hemorrhagic diatheses and complex disorders of hemostasis
Thrombophilic disorders
Iron, sideropenic anemia, iron overload
Block II - Circulatory system disorders
Pathophysiology of circulation using simulation models
Pathophysiology of shock and circulatory failure
Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction
Block III - Respiratory system, internal environment
Pathophysiology of respiration using simulation models
Cystic fibrosis, immunology of bronchial obstruction
Disorders of the internal environment - acid-base chemistry
Annotation
Pathophysiology is a bridge between theoretical medical subjects and clinical studies. Pathophysiology studies changes in the human body as influenced by various diseases.
It collects data regarding the causes of various diseases and data regarding the functional changes occurring in various organs systems, organs, tissues and cells. The course of the pathological physiology consists from lectures and seminars.
Students are motivated to actively participate in the teaching during seminars and some home work with the aim to prepare them for continuous studies of pathophysiology during their clinical studies and as a part of the continuous medical education. The two semester course deals with pathophysiology of different organ systems of the body, roughly corresponding to clinical specialization, particularly in the internal medicine.
General mechanism causing and underlying diseases are included into the teaching curriculum.