Sylabus
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1. Principal aspects of malignancies, tumor pathogenesis, cancer stem cells *
2. Genetic predispositions, hereditary cancer syndromes *
3. Cell signaling, growth factor receptor pathways *
4. DNA damage and repair, epigenetic alterations *
5. Cell cycle, ploidy, chromosomal aberrations *
6. Apoptosis, cell immortalization *
7. Cancer cell metabolism *
8. Tumor radiobiology *
9. Angiogenesis, metastatic process, circulating tumors cells, cell-free DNA and miRNAs *
10. Immune response, tumor microenvironment, microbiome *
11. Methods in molecular biology, predictive testing, tumor molecular classification *
12. Molecular-based therapy, gene therapy
Anotace
It is an interdisciplinary cross-curricular subject that summarizes the essential aspects of the molecular biology of malignant tumors and puts them in the context of their clinical behavior, course of the disease and response to treatment. Each topic covers basic biological facts and principles, their specific application in the development of oncological diseases, method of detection, possibilities of use in the diagnosis and treatment of tumors.