Syllabus
General Pharmacology 2023/2024 week
Teach.Unit No.
LECTURES
Teach.Unit No.
PRACTICALS 1 2/10-6/10 1
Introduction to pharmacology. Principles of pharmacokinetics
J. Slíva 2
Basics of drug prescription. Introduction to pharmacology.
Basic terminology. Organization of teaching and testing.
J. Slíva, P. Potměšil 2 9/10-13/10 3
Biotransformation and elimination of drugs, drug interactions.
J. Slíva 4
QUIZ - Basics of pharmacokinetics
Pharmacokinetics, single and repeated dose administration, changes in disease states ‒ computer simulations
P. Potměšil 3 16/10-20/10 5
Autonomic pharmacology – parasympathetic system.
M. Lapka 6
QUIZ - Autonomic pharmacology – parasympathetic system.
M agonists, antagonists, Nicot. agonists, antagonists, spasmolytics, prokinetics, antiglaucomatics, peripheral muscle relaxants.
Case study, drug prescription
M. Šustková 4 23/10-27/10 7
Autonomic pharmacology – sympathetic system.
Ch. Charalambous 8
QUIZ - Autonomic pharmacology – sympathetic system
Alfa/beta agonists, antagonists, catecholamines.
Case study, drug prescription.
P. Potměšil 5 30/10-3/11 9
Drugs acting via dopamine, serotonin, histamine
M. Šustková 10 1st TEST for credit – PHARMACOKINETICS (basic principles, biotransformation and elimination of DRUGS, TU drugs TU 1- 4)
QUIZ - Biotransformation and elimination of drugs, drug interactions.
Types of pharmacokinetic drug interactions (level of biotransformation and elimination) use of MICROMEDEX, AISLP
A. Nazmudtinová 6 6/11-10/11 11
Drugs acting by inhibition of enzymes
J. Slíva 12
QUIZ - Drugs acting via dopamine, serotonin, histamine
Important drugs acting via dopamine, serotonin, histamine - antipsychotics, antiparkinsonics, antimigrenics, antiemetics, antihistaminics, H2-antagonists etc.
Case study, drug prescription
A. Khryaková 7 13/11-17/11 13
Drugs acting via ion channels and transporters
P. Potměšil 14 2nd TEST for credit – PHARMACODYNAMICS I (Pharmacology of autonomic nervous system – TU 5, 6, 7, 8)
QUIZ - Drugs acting by inhibition of enzymes
Cholinesterase inhibitors, inhibitors of ACE, cyklooxygenase, HMG-CoA reductase, PDE, etc.
Case study, drug prescription A. Čertilina 8 20/11-24/11 15
Pharmacological options of affecting the essentials regulatory systems - an example of control of blood pressure and systemic circulation
P. Potměšil 16
QUIZ - Drugs acting via ion channels and transporters
QUIZ - Pharmacological options of affecting the essentials regulatory systems - an example of control of blood pressure and systemic circulation
Examples of drugs acting on ion channels – calcium channel blockers, local anaesthetics, IPP, antidepressants, etc.
Case study, drug prescription
Treatment of hypertension - case studies, drug prescription
P. Potměšil 9 27/11-1/12 17
Drug and remedy addiction
M. Šustková 18
Phytotherapy
M. Šustková, A. Khryaková 10 4/12-8/12 19
ATMP Drugs. Biologic therapy, gene therapy
J. Slíva 20 3rd TEST for credit PHARMACODYNAMICS II (pharmacology of selected receptors, ion channels, enzymes and regulatory systems – TU 9, 11-16, 18)
QUIZ - Basic terms in drug and remedy addiction
Alcohol, tobacco and drugs
M. Šustková 11 11/12-15/12 21
Adverse drug reactions. Regulatory agencies (EMA). Pharmacovigilance
Pharmacoeconomics.
M. Votava 22
Pharmacovigilance in common praxis
M. Pohl 12 18/12-22/12 23
Drug discovery and development. Evidence of drug efficacy. EBM. Placebo.
M. Votava 24
QUIZ - Drug discovery and development. Evidence of drug efficac
Annotation
In the subject of General pharmacology (in winter semester of the 3rd section of study) there are taught essentials of pharmacodynamics (e.g. interactions of drugs with receptors, molecular targets for drug action), fundamentals of pharmacokinetics (e.g. the half-life and its uses), drug interactions, introduction to clinical trials of drugs, adverse drug reactions, etc. Students are also taught pharmacology of autonomous system, pharmacology of most important neurotransmitter systems, pharmacology of enzymes and of transport proteins and a prescription writing.