Regulation of transcription and tumorous transformation of cells

Syllabus

1. Regulation of transcription in eukaryotic cells

2. Oncoproteins of DNA viruses and tumor suppressor genes.

3. Defects in cell cycle regulation and apoptosis during malignant transformation

4. Transformation and immortalization of cells in the cell culture

5. Practical demonstration of cell cultivation and gene transfer into cultured cells

6. Clinical aspects of gene mutations in oncology

Annotation

Basic course providing the students with principles of transcription of DNA and the molecular mechanisms which play a role in the malignant transformation of the cell.