Syllabus
Syllabus - Reproductive Genetics and Reproductive Medicine
Time schedule
Basics of reproductive genetics and periconceptional medicine. Causes offertility - exogenic, endogenic, psychogenic and genetic. Possible prevention and therapy of fertility disorders. Unexplained infertility. Ethical and legal aspects of reproductive medicine.
Clinical and diagnostic preparation of women. Therapy of ovarial, tubal anduteral factors of subfertility. Pharmacotherapy of COH. Complications of IVF. Patient care. Gonadal protecion in oncological patients.
Basics of andrology and andrological examinations.
Polymorphisms of hormonal receptors and Y chromosome.
Immunological problems of infertility.
Specialized genetic counselling. Indications and methods of IUI and IVF. Clinical embryology. Indications and importance of ICSI. Invasive methods ofsperm extraction. Cryopreservation of gametes, embryos, testicular and ovariantissues. Donors of gametes and embryos. Recurrent abortions. Surrogatemothership, adoption.
Molecular genetic diagnostics in assisted reproduction. Mutations andpolymorphisms of CFTR gene. Thrombophilic mutations.
Molecular-cytogenetic diagnostics of gametes, polar bodies, blastomeres andtrophoectoderm.
Preimplantaiton and prenatal diagnosis. Prenatal screening in Ist and IInd trimester.
Development of child after IVF. Hormonal protection of gonads.
Discussion and credit.
Time schedule:
Monday 8th April 2013, Lecture room SP2 14:00 - 15:00 Introduction, genetic counselling, ethical and legal issues (doc. MUDr. Milan Macek sr., CSc.) 15:00 - 16:30 Periconception medicine: Reproductive risks in males (doc. MUDr. Milan Macek sr., CSc.) 16:30 - 17:30 Clinical andrology (MUDr. Jan Diblík, Ph.D.) 17:30 - 18:00 Special andrological methods of DNA instability detection (Ing. Tomáš Slavík, CSc.)
Tuesday 9th April 2013, Lecture room SP2 14:00 - 15:30 Genetic syndromes with reproducitve disorders, gonadal protection in oncological patients (doc. MUDr. Marta Šnajderová, CSc.) 15:30 - 16:00 Reproductive care for oncological patients (doc. MUDr. Milan Macek sr., CSc.) 16:00 - 18:00 Reproductive risks in females and their diagnostics (doc. MUDr. Milan Macek sr., CSc.)
Wednesday 10th April 2013, Lecture room SP2 14:00 - 14:45 Dysfertility: nomenclature, epidemiology, diagnostics (MUDr. Karel Hynek) 14:45 - 15:30 Dysfertility: pharmacotherapy, surgical treatment, assisted reproduction methods (MUDr. Gabriela Stránská) 15:30 - 17:00 Clinical embryology and cryopreservation (doc. MUDr. Milan Macek sr., CSc.) 17:00 - 18:00 Molecular-cytogenetic diagnosis (Mgr. Jana Drábová)
Thursday 11th April 2013, Lecture room SP2 14:00 - 15:00 Imunological aspects of reproduction (RNDr. Dana Nováková) 15:00 - 15:30 Preimplantation diagnosis of chromosomal aberrations (MUDr. Jan Diblík, Ph.D.) 15:30 - 16:30 Prenatal diagnosis and therapy, prenatal screening (doc. MUDr. Milan Macek sr., CSc.) 16:30 - 17:30 Molecular-genetic factors of reproducitve disorders: CFTR gene and thromophilic mutations (MUDr. Marek Turnovec) 17:30 - 17:50 Hormonal polymorphisms, importance of Y chromosome aberrations in males reproduction (doc. MUDr. Milan Macek sr., CSc.) 17:50 - 18.00 Credit (doc. MUDr. Milan Macek sr., CSc.)
Annotation
Současný stav, možnosti a perspektivy reprodukční medicíny a reprodukční genetiky na základě pokroku reprodukční endokrinologie, molekulární diagnostiky poruch reprodukce a nejnovějšího pokroku biologie, klinické genetiky, molekulární genetiky a cytogenetiky.