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Lékařská biologie I

Předmět na 2. lékařská fakulta |
DA0102337

Tento text není v aktuálním jazyce dostupný. Zobrazuje se verze "en".Sylabus

MEDICAL BIOLOGY I. first year, summer term

History of biology, the central dogma

Darwin, Mendel, misuse of genetics, Griffith, Avery, Watson, Crick, the central dogma

Genetic code, gene structure and expression flow of genetic information, genetic code genes and expression, regulation

Mutations and DNA repair mutation and polymorphism, types of mutations, types of reparations

Chromatin structure structure of chromosome, types of chromosomes, human chromosomes, sex determination

Eukaryotic cell differences between prokaryotic and eukaryotic cell, characteristics of eukaryotes

Prokaryota and viruses archebacteria, eubacteria, reproduction of bacteria, recombination, basic structure of viruses, viral nucleic acids, viruses and transposons

Cell cycle and its regulation cyclins, cyclin-dependent kinases, regulation in prokaryotes and multicellular eukaryotes, cultivation of cells

Basic laws and modes of heredity

Mendel laws, monogenic inheritance, mosaicism, genomic imprinting

Dihybridism and gene interactions mitochondrial inheritance, dihybridism, interaction of non-allelic genes, multifactorial inheritance

Gene linkage gene mapping, crossing over, recombination, gene linkage phase, linkage analysis and its use in medicine

Population genetics 1 definitions, genetic variability the Hardy-Weinberg law and its use

Population genetics 2 evolutionary factors and their impact, non-random mating, mutation, selection, gene drift, gene flow (migration)

Clinical genetics genetic counselling: indication, methods, screening in pregnancy, prenatal diagnosis