Syllabus
MEDICAL BIOLOGY I. first year, summer term
History of biology, the central dogma
Darwin, Mendel, misuse of genetics, Griffith, Avery, Watson, Crick, the central dogma
Genetic code, gene structure and expression flow of genetic information, genetic code genes and expression, regulation
Mutations and DNA repair mutation and polymorphism, types of mutations, types of reparations
Chromatin structure structure of chromosome, types of chromosomes, human chromosomes, sex determination
Eukaryotic cell differences between prokaryotic and eukaryotic cell, characteristics of eukaryotes
Prokaryota and viruses archebacteria, eubacteria, reproduction of bacteria, recombination, basic structure of viruses, viral nucleic acids, viruses and transposons
Cell cycle and its regulation cyclins, cyclin-dependent kinases, regulation in prokaryotes and multicellular eukaryotes, cultivation of cells
Basic laws and modes of heredity
Mendel laws, monogenic inheritance, mosaicism, genomic imprinting
Dihybridism and gene interactions mitochondrial inheritance, dihybridism, interaction of non-allelic genes, multifactorial inheritance
Gene linkage gene mapping, crossing over, recombination, gene linkage phase, linkage analysis and its use in medicine
Population genetics 1 definitions, genetic variability the Hardy-Weinberg law and its use
Population genetics 2 evolutionary factors and their impact, non-random mating, mutation, selection, gene drift, gene flow (migration)
Clinical genetics genetic counselling: indication, methods, screening in pregnancy, prenatal diagnosis