Syllabus
Immunology - 3rd year - Dentistry SS 2023/2024
Seminars take place in the seminar room of the Department of Immunology and Allergology, entrance C, 2nd floor, room No 345, 9.00 – 10.40 23. 2. 2024 Mgr. Ochotná Jitka 1. The immune system and its importance for homeostasis. Antigen. Mechanisms of the immune system and their cooperation. 2. Component parts of the immune system (organs, cells, substances) and their function. 3. Non-specific cellular and humoral immune mechanisms (characteristics, function). 4. Specific cellular and humoral immune mechanisms (characteristics, function). 5. Phagocytosis (phagocytes, their functions and importance). 6. Complement, pathways of activation, biological significance. 7. Basophils and mast cells and their role in the immune reactions. 8. 3. 2024 Mgr. Ochotná Jitka 8. Natural killer cells, their characteristics, and their function. Interferons. 9. HLA system (classes, polymorphism, typing). 10. Binding of peptides to MHC. Antigen presentation (function, purpose). 11. T-lymphocytes (ontogenesis, selection, surface markers, subpopulations, functions). TCR. 12. Th1 based immune reaction. 13. Th2 based immune reaction. 14. Tc based immune reaction. 22. 3. 2024 MUDr. Vachová Martina, Ph.D. 15. B-lymphocytes - ontogenesis, surface markers, function. BCR. Ontogenesis of antibody production. 16. Immunoglobulins (structure, classes). Genetic background of immunoglobulin production. Class switching. Anti-idiotypes. 17. Immunoglobulins (functions of different isotypes). 18. Antibodies based immune reaction (primary, secondary). 19. Mucous and cutaneous immune system (Barrier functions of the human body and defense mechanisms). 20. External regulation of immune response (possibilities, purposes). 5. 4. 2024 Mgr. Ochotná Jitka 21. Immune mechanisms of inflammation (local and systemic reaction). 22. Physiological mechanisms of regulation of the immune system. Cytokines (classification according to the function). 23. Defense against extracellular pathogens (bacteria and unicellular parasites). 24. Defense against intracellular pathogens (bacteria, fungi and unicellular parasites). 25. Anti-viral defense. 26. Defense against multicellular parasites. 19. 4. 2024 Mgr. Ochotná Jitka 27. Tumor immunology - tumor antigens, mechanisms of defense. 28. Alloimmune reaction. Types of transplantations and immunological examination before transplantation. Immunologically privileged tissues. 29. Types of graft rejection and their mechanisms. GvH disease. Principles of materno-foetal tolerance. Rh incompatibility 30. IgG and IgM based immunopathological reaction (reaction of hypersensitivity type II). 31. Immunocomplex based immunopathological reaction (reaction of hypersensitivity type III). 3. 5. 2024 MUDr. Liška Martin, Ph.D. 32. Acquired immunodeficiencies - causes, mechanisms involved. AIDS. 33. Primary immunodeficiencies - clinical manifestations, examples. 34. Hereditary angioedema (pathophysiology, clinical manifestations, treatment). 35. Examples of systemic autoimmune diseases. Significance of autoantibodies.
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Annotation
In this subject, the student acquires basic knowledge about the structure and function of the immune system, acquaints with pathogenesis, clinical manifestations, and treatment of the most important immunopathological diseases.