Syllabus
Pathological physiology I: Syllabus of the subject - General medicine
Individual topics can be moved between the subjects pathological physiology I and pathological physiology II.
General pathophysiology I
Introduction to the subject, basic terms, disease and its course
Etiological factors
Classification of etiological and risk factors, particular intrinsic and extrinsic etiological factors
Pathophysiology of wound healing
Developmental disorders
Causes and mechanisms of developmental disorders, diseases linked to a certain age
Gametopathy, blastopathy, embryopathy, fetopathy, perinatal damage
Growth disorders
Aging, terminal states, death of an individual, cell death
Pathophysiology of immunity
Immunodeficiency, allergy, autoimmune diseases, inflammation, transplantation
Pathophysiology of thermoregulation, fever
Pathophysiology of tumors
Special pathophysiology I
Pathophysiology of the lymphatic system
Pathophysiology of the blood
Changes of blood volume and composition
Disorders of erythrocytes, anemia, polycythemia, polyglobulia, hemolysis
Pathophysiology of leukocytes – changes of number, disorders of function, leukemias
Bleeding, hemorrhagic diathesis, thrombotic states
Pathophysiology of the cardiovascular system
Inborn and acquired heart defects
Disturbances of peripheral blood circulation, atherosclerosis, endothelial dysfunction
Ischemic heart disease, arrhythmias, arterial hypertension, thromboembolic disease
Cardiac insufficiency and failure, circulatory shock
Heart hypertrophy and dilatation, cardiomyopathy, heart inflammations
Multiorgan dysfunction and multiorgan failure
Pathophysiology of the endocrine system
General causes of diseases of the endocrine glands, mechanisms of endocrine disorders
Pathophysiology of individual endocrine structures and hormones
Pathophysiology of the reproductive system
Pathophysiology of the bones
Pathophysiology of the muscles
Manifestations of diseases of the skeletal muscles and their innervation
Myopathies, muscular dystrophias, myositis, rhabdomyolysis, crush syndrome, compartment syndrome, malignant hyperthermia
Acid-base balance and its disorders
Pathophysiology of body fluids
Pathophysiology of mineral metabolism
Pathophysiology of the gastrointestinal tract
Pathophysiology of the oral cavity, esophagus, stomach, gut, exocrine pancreas
Dysphagia, nausea, vomiting, dyspepsia, constipation, diarrhea, gastrointestinal tract bleeding
Practical knowledge and skills I
Principles of science, statistics, injection technique, anesthesia, pathophysiological aspects of wound treatment, use of electricity in medicine, electrocardiography, blood pressure measurement, examination of hemorrhagic diatheses
Detailed syllabus for pathological physiolopgy I and subsequent subject pathological physiology II: http://patofyziologie.lfp.cuni.cz/
Annotation
The content of the subject pathological physiology I is general pathophysiology and part of special pathophysiology. General pathophysiology deals with the general principles of origin, development and course of diseases and pathological conditions and pathological phenomena of a general nature.
The subject of special pathophysiology is the etiology and pathogenesis of diseases and disorders of specific organs, organ systems and particular diseases. Practical skills related to basic medical procedures and their pathophysiological aspects in the context of theoretical knowledge are also taught.
Prerequisites are knowledge from the fields to which pathological physiology follows, i.e., anatomy, histology, embryology, biology, genetics, chemistry and biochemistry, biophysics, physiology and microbiology. The subject of pathological physiology I forms an integral complex with the follow-up subject pathological physiology II, the content is interrelated and complementary.