Sylabus
The syllabus:
Lesson I
Gastrointestinal diseases of infectious origin
Pathophysiology of gastrointestinal diseases (osmotic, inflammatory, secretory mechanisms of diarrhoea)
Incidence and epidemiology of infectious gastroenterites
Infectious gastroenteritis of viral and bacterial origin and foodborne toxigenic diarrhoea (clinical course, diagnosis, therapy, prophylaxis)
Differential diagnosis of infectious and non- infectious diarrhoea
Complications of infectious diarrheal diseases
Clinical picture, epidemiology, pathophysiology, complications, therapy, prophylaxis of Salmonellosis, Salmonella typhi and paratyphi, Cholera, E.coli gastroenteritis, Campylobacteriosis, Yersinia enterocolitica, Shigellosis, pseudomembranous enterocolitis, Rotavirus, Adenovirus, Norwalk virus gastroenterites and other viral gastroenterites, foodborne toxigenic diarrhea
Hemolytic-uremic syndrome
Aspects of prophylaxis of infectious diarrhea (vaccination)
Lesson II
Infectious inflammatory diseases of the liver
Pathophysiology of viral hepatites
Incidence and epidemiology of viral hepatites
Acute viral hepatitis A - pathophysiology, epidemiology, clinical course, diagnosis (laboratory and serologic markers), therapy, prophylaxis specific and non-specific
Acute viral hepatitis B - pathophysiology, epidemiology, clinical course, diagnosis (laboratory and serologic markers), therapy, prophylaxis specific and non-specific
Acute viral hepatitis C - pathophysiology, epidemiology, clinical course, diagnosis (laboratory and serologic markers) therapy, possibility of prophylaxis
Viral hepatitis D - pathophysiology, epidemiology, clinical course, diagnosis (laboratory and serologic markers), therapy, possibility of prophylaxis
Acute viral hepatitis E- pathophysiology, epidemiology, clinical course, diagnosis (laboratory and serologic markers) , therapy, prophylaxis
Viral hepatites G, F, TTV - new causes of viral hepatites?
Complications and sequelae of acute viral hepatites
Differential diagnosis of acute hepatites (infectious and non-infectious origin)
Chronic hepatitites B and C - incidence, clinical picture, laboratory and serologic markers, possibility of therapy and prophylaxis nowadays
Reye´s syndrome
Lesson III
Exanthematic diseases
Types of exanthems commonly, pathogenesis
Exanthematic diseases of bacterial and viral origin
Scarlet fever – epidemiology, pathogenesis, clinical course, diagnosis, therapy, and differential diagnosis
Toxic shock syndrome – history, epidemiology, pathogenesis, clinical course, diagnosis, therapy
Kawasaki syndrome – history, epidemiology, pathogenesis, clinical course, diagnosis, therapy
Rubella – epidemiology, pathogenesis, clinical course, diagnosis, differential diagnosis, complications, rubella in pregnancy, prophylaxis
Measles – epidemiology, pathogenesis, clinical course, diagnosis, complications, differential diagnosis, measles and immunity of organism, prophylaxis
Varicella (Chickenpox) – epidemiology, pathogenesis, clinical course, diagnosis, differential diagnosis, therapy, complications, varicella in pregnancy, varicella and immunodeficiency, prophylaxis
Herpes zoster – epidemiology, pathogenesis, clinical course, diagnosis, therapy
Megalerythema infectiosum – epidemiology, pathogenesis, clinical course, diagnosis, differential diagnosis, therapy, complications, megalerythema infectiosum in pregnancy
Exanthema subitum (Roseola infantum)– epidemiology, pathogenesis, clinical course, diagnosis, therapy, complications
Lesson IV
Lymphadenopathy
Occurrence of lymphadenopathy commonly, quick diagnosis is necessary
Viral causes of lymphadenopathy:
Adenovirus – epidemiology, clinical course, diagnosis, therapy
Infectious mononucleosis /virus Epstein-Barr, cytomegalovirus/ - epidemiology, pathogenesis, clinical course, diagnosis, therapy, complications
Parotitis epidemica (Mumps) – epidemiology, pathogenesis, clinical course, therapy, complications, therapy if complications, prophylaxis
Rubella, measles – clinical course exanthematic diseases
Gingivostomatitis herpetica (Aphthous stomatitis) – epidemiology, pathogenesis, clinical course, therapy, differential diagnosis
Bacterial cases of lymphadenopathy:
Infections of streptococci – angina, lymphadenopathy – epidemiology, pathogenesis, clinical course, diagnosis, therapy, complications
Infections of staphylococci – angina, lymphadenopathy, bacterial parotitis – epidemiology, pathogenesis, clinical course, diagnosis, therapy, complications
Tularaemia – history, epidemiology, pathogenesis, clinical course, types of tularaemia, diagnosis, therapy, complications
Diphtheria – epidemiology, pathogenesis, clinical course, diagnosis, therapy, complications, prophylaxis
Listeriosis – epidemiology, pathogenesis, clinical course, diagnosis, therapy, listeriosis in immunodeficiency
Yersiniosis – epidemiology, pathogenesis, clinical course, diagnosis, therapy
Parasitic cause of lymphadenopathy:
Toxoplasmosis – history, epidemiology, pathogenesis, clinical cause, diagnosis, therapy, toxoplasmosis in pregnancy, toxoplasmosis in immunodeficiency
Lesson V
Parasitic diseases
Malaria – history, epidemiology, pathogenesis, occurrence of malaria in the world, prophylaxis
Types of malaria, clinical course, diagnosis, therapy, complications
Amoebosis, giardiosis, echinococcosis, teniarhynchosis, hymenolepiosis, trichinosis (trichinellosis), ankylostomosis, askaridosis, enterobiosis, toxocarosis – etiology, epidemiology, clinical course, diagnosis, therapy, prophylaxis
Lesson VI
Infections of the nervous system – bacterial meningitis
Epidemiology. Ethiology. Clinical features. Diagnostic approach. Laboratory investigations, CSF features, serological tests, CT, MRI. Differential diagnosis. Treatment. Prognosis. Prevention
Acute meningitis – pyogenic: haemophilus meningitis, pneumococcal meningitis, meningococcal infection. Neonatal meningitis
Posttraumatic meningitis
Complications of meningitis. Brain abscess
Listeriosis and Listeria meningitis
Tuberculous meningitis
Fungal and parasitic infections of CNS (Cryptococcal meningitis, Toxoplasmosis)
Septicaemia. Septic shock
Lesson VII
Infections of the nervous system – aseptic meningitis
Viral meningitis and encephalitis /HSV1, 2, VZ, EBV, CMV, AD, PA, enteroviral, TBE
Postinfective and postvaccination encephalitis
Parotitis epidemica (Mumps) and complications (CNS). Encephalitis herpetica
Poliomyelitis and other enteroviral infections. Polio-like illness. Guillain - Barre syndrome
Polyneuritis
Tick borne infections /TBE, Lyme disease (borreliosis), ehrlichiosis, rickettsiosis, tularaemia/
Leptospirosis
Slow viral infections of the CNS (spongiform encephalopathies)
Rabies. Wound septicaemia (P. multocida)
Botulism
Tetanus
Lesson VIII
Respiratory tract infections
Herpesvirus infections (HSV-1, HSV-2), Chickenpox and herpes zoster
Influenza, parainfluenza, other viral infections of respiratory tract: RS virus, adenovirus, enterovirus, rhinovirus, acute obstructive laryngitis /croup/
Mycoplasmal and chlamydial infections /psittacosis, ornithosis/
Bacterial respiratory tract infections (Haemophilus influenzae infections, Pertussis and whooping cough syndrome). Actinomycosis
Anaerobic infections
Lesson IX
AIDS
AIDS as a consequence of HIV infection
History, epidemiology, pathogenesis, clinical pictures of various stages of HIV/AIDS, opportunistic infections and tumours associated with AIDS, laboratory and serological diagnosis, differential diagnosis, complications, advances in the treatment of HIV-infection (cART, HAART), vaccines, HIV and society.
Fungal infections. New herpetic viruses. Infections in immunocompromised people. Opportunistic infections
Literature recommended for students:
Mandal, B.K., Wilkins, E.G.L., Dunbar, E.M.,Mayon-White,R.T.: Infections Diseas
Anotace
Seznámení posluchačů s nejčastěji se vyskytujícími a klinicky nejdůležitějšími infekčními nemocemi s důrazem na mezioborovou spolupráci při jejich diagnostice a terapii.