Pathological Physiology I

Syllabus

Lectures

Lecturers prof. MUDr. Miroslav Kuba, DSc. prof. MUDr. Zuzana Kubová, CSc.

MUDr. Marie Chutná

MUDr. Lenka Miščík Ramešová  

Organism and Environment, Adaptation. Etiology and Pathogenesis. Health Versus Disease. Clinical and Biological /Somatic/Death. (Kuba)

Alterations in Fluid Volume. Disorders of Osmolarity, Etiology and Pathogenesis of Oedema. Hyponatremia, Hypernatremia. (Kubová)

Hypokalemia, Hyperkalemia. Acidosis. Alkalosis. (Kubová)

Hypersensitivity reactions. Allergies. Autoimmune disorders. Post-transplantation responses. Immunodeficiencies. (Chutná)

Disorders of Calcium and Phosphorus Metabolism, Magnesium Imbalances. Osteoporosis, Osteomalacia, Renal Osteodystrophy. Pathophysiology of Cramps. (Kuba) TEST - homeostasis disorders. (Kubová)

Disorders of Peripheral Circulation. Syncope. Circulatory Shock. Thrombophilic states. DIC. (Kubová) RETAKE TEST.

Blood Transfusion, Complications, Erythroblastosis Fetalis. Abnormalities of Haemostasias and Coagulation. (Kuba)

Pulmonary Circulation, Ventilation/Perfusion Ratio. Gas Diffusion Disorders. Obstructive Respiratory Diseases. Restrictive Pulmonary Diseases. (Kubová)

Pulmonary Hypertension, Pulmonary Oedema. ARDS. Respiratory Failure. Hypoxia. Hyperoxia, Hyperbaria, Decompression. (Kubová) TEST - haemostasis disorders. (Kuba)

Dyslipoproteinemia. Endothelial Dysfunction. Effects of Nitric oxide. Arteriosclerosis. (Kubová) RETAKE TEST.

Ischemic Heart Disease. Myocardial Infarction and its Complications. Acquired Valvular Heart Disease. Congenital Heart Defects. (Kuba)

Heart Failure - Etiology and Pathogenesis. Compensatory Mechanisms in Heart Diseases. (Kuba)

Arterial Hypertension - Etiology and Pathogenesis. Arterial Hypotension. (Kuba) TEST - pathophysiology of the cardiovascular system. (Kuba)

Bone Marrow Depression. Leukemia, Lymphoma. Myeloma. (Miščík Ramešová) RETAKE TEST.  

Practical classes and seminars

Teachers prof. MUDr. Miroslav Kuba, DSc. prof. MUDr. Zuzana Kubová, CSc.

MUDr. Jana Langrová, Ph.D.

MUDr. Jana Szanyi, Ph.D.

MUDr. Marie Chutná

MUDr. Lenka Miščík Ramešová

 Seminars

Introduction to practical classes. Neoplasia, Neoplasm-Host Interaction (Effects).

Inflammation. Sepsis. SIRS. Fever. Hyperthermia. Hypothermia and reaction of organism to cold.  

Stress, General Adaptation Syndrome, Psychosomatic Diseases. 

Pathophysiology of Pain.

Anemias - classification, consequences. Polycythemia. Microscopic findings in peripheral blood. 

 Practical courses

ECG I - description

ECG II - description.

ECG III - practice.

ECG IV - practice, self-ECG recordings.

ECG V - ECG TEST

Computer spirometry - recordings and evaluation. 1/2 group; Bicycle ergometry - adaptation of the cardio-vascular system to a physical load. 1/2 group

Bicycle ergometry - adaptation of the cardio-vascular system to a physical load. 1/2 group; Computer spirometry - recordings and evaluation. 1/2 group

Annotation

Pathological physiology is a preclinical subject that deals with etiology (causes) and pathogenesis (development) of body dysfunctions. It aims to understanding of mechanisms that can influence the origin and course of diseases, which is necessary for correct causal and individualized treatment.

In the first term students are taught general principles of diseases and their effect on organism. A part of the study is devoted to states that accompany the specific diseases e.g. effects of inflammation, hypoxia, and internal environment disorders.

Further students gain a comprehensive overview of etiology and pathogenesis of blood, cardiovascular and respiratory diseases. Practical part of the study is oriented mainly to acquiring knowledge of registration and description of ECG.

In Computer spirometry practical class the students get information about most frequent spirometry findings in respiratory diseases.