Syllabus
Teachers Prof. Stanislav Micuda, M.D., Ph.D. Assoc. Prof. Dr. Martin Sterba, Ph.D. Assoc. Prof. Jaroslav Chladek, M.Sc., Ph.D. Jolana Schreiberová, M.D., Ph.D. PharmDr. Olga Lenčová, Ph.D. Lectures The lectures will take place face-to-face in MS Teams in the form of "live" transmission, or an academic staff member will prepare a Powerpoint presentation with inserted voice comments. Video of the lecture will then be uploaded to our Moodle page. The presenting teacher will be online to answer questions during class time or will be available to students for consultations or questions about the lecture in another adequate way. The method of presentation will be up to the individual lecturer. The students will be informed about this in advance. The recorded lectures will be permanently available on the corresponding Moodle page.
1. Basic principles of pharmacology. Pharmacodynamics.2. Pharmacokinetics. Pharmacokinetic parameters.
3. Adverse and toxic effects. Drug interactions.4. Cholinergic transmission: cholinergic agonists and antagonists.
5. Noradrenergic transmission: adrenergic agonists and antagonists.
6. Opioid analgesics. Practical courses & seminars
1. Basic principles of pharmacology. Pharmacodynamics.
1.1. Nature of drug targets, receptors and their types.
1.2. Well-established second messengers.
1.3. Dose-response curve.
1.4. Potency and efficacy.
1.5. Agonists and antagonists.
1.6. Up and down regulations.
1.7. Variation in drug responsiveness.
1.8. Practical demonstrations: PC simulation - Isolated ileum stimulation. The demonstration will be performed by the lecturer.
1.9. Analysis of cases studies.
1.10. Test2. Pharmacokinetics of the drugs.
2.1. Main mechanisms determining pharmacokinetics of a drug (physico-chemical properties, permeation through biomembranes, binding).
2.2. Absorption, distribution, metabolism, excretion (ADME).
2.3. Pharmacokinetic parameters, pharmacogenetics, bioavailability, bioequivalence.
2.4. Practical demonstrations: PC simulation using the PkSims software. The demonstration will be performed by the lecturer.
2.5. Analysis of cases studies.
2.6. Test3. Adverse and toxic effects of drugs. Drug interactions. Drug development.
3.1. The seminar on: the above given topics, drug information and its sources.
3.2. Practical demonstrations: SPC (Summary of Product Characteristics), AISLP (Electronic version of the Czech Drug Formulary). The demonstration will be performed by the lecturer.
3.3. Analysis of cases studies.
3.4. Test4. Drugs affecting cholinergic transmission: cholinergic agonists & antagonists - seminar.
4.1. Practical demonstrations: PC simulation - Cardio heart rate and blood pressure (in vivo). The demonstration will be performed by the lecturer.
4.2. Analysis of cases studies.
4.3. Test5. Drugs affecting adrenergic transmission: adrenergic agonists & antagonists - seminar.
5.1. Practical demonstrations: PC simulation - Cardio heart rate and blood pressure (in vivo). The demonstration will be performed by the lecturer.
5.2. Analysis of cases studies.
5.3. Test6. Control of pain - seminar.
6.1. Basic and clinical pharmacology of analgesics, both opioid and non-opioid (including NSAIDs!).
6.2. Analysis of cases studies.
6.3. Test7. Neuroleptic, antidepressant agents, anxiolytics - microlesson and seminar.
7.1. The seminar on: Basic and clinical pharmacology of drugs used in psychotic, affective and anxiety disorders.
7.2. Video presentation: Extrapyramidal syndrome due to neuroleptics.
7.3. Analysis of cases studies.
7.4. Test8. Hypno-sedatives, antiparkinsonics and antiepileptics - microlesson and seminar.
8.1. The seminar on: Basic and clinical pharmacology of hypno-sedative, antiparkinsonic and antiepileptic drugs.
8.2. Practical demonstrations: Therapeutic drug monitoring (TDM) in antiepileptic therapy.
8.3. Analysis of cases studies.
8.4. Test9. Skeletal muscle relaxants. General and local anesthetics.
9.1. The seminar on: Local anesthetics and skeletal muscle relaxants.
9.2. Microlesson: General anesthetics.
9.3. Analysis of cases studies.
9.4. Test.
9.5. The Credit. Notes Students are supposed to be theoretically prepared on each practical lesson/seminar. Consultations with any teacher of the Department of Pharmacology are possible by prior arrangement.
Annotation
Pharmacology I. is an introductory subject to the field of pharmacology. The teaching is therefore focused at the beginning on presenting the basic principles associated with general pharmacology.
The student is introduced to the laws of pharmacodynamics, i.e. the effects of drugs and pharmacokinetics, i.e. the fate of the drug in the body. Chapters describing how drugs work in the body are gradually introduced, starting at the molecular level and ending with the body's overall reaction to the drug.
The fate of the drug in the body is analyzed at the level of absorption, distribution, metabolism and excretion, including the mathematical expression of these processes. Then students are introduced to the issue of pharmacotherapeutic complications, such as adverse effects and drug interactions, and their prevention using effect or plasma concentration monitoring.
This is followed by familiarizing with the pharmacogenetics, drug development, and clinically significant databases of medicinal products and their effective use. The chapters devoted to general pharmacology are followed by courses dedicated to the special pharmacology of drugs used in central and peripheral nervous system diseases.
Chapters devoted to the autonomic nervous system, pain treatment, schizophrenia, depression, sleep and anxiety disorders, epilepsy, neurodegenerative diseases, and spasticity are successively discussed. Practical teaching is oriented towards using acquired knowledge to solve specific pharmacotherapeutic situations that can be observed in clinical practice.