Syllabus
Lectures
The lectures will take place face-to-face in MS Teams in the form of "live" transmission, or an academic staff member will prepare a Powerpoint presentation with inserted voice comments. Video of the lecture will then be uploaded to our Moodle page. The presenting teacher will be online to answer questions during class time or will be available to students for consultations or questions about the lecture in another adequate way. The method of presentation will be up to the individual lecturer. The students will be informed about this in advance. The recorded lectures will be permanently available on the corresponding Moodle page.
Lecturers
Prof. Stanislav Mičuda, M.D., Ph.D.
Assoc. Prof. Martin Štěrba, PharmD., Ph.D
Assoc. Prof. Jaroslav Chládek, MSc., Ph.D.
Antihistamines, drugs affecting hemostasis. (Chládek, 3)
Antiarrhythmics, drugs with positive inotropic action. (Štěrba, 3)
Drugs affecting RAAS, diuretics. (Štěrba, 3)
Drugs affecting vascular tonus, non-insulin antidiabetic agents. (Štěrba, 3)
Pharmacology of corticoid and thyroid homones. (Mičuda, 3)
Pharmacology of sexual hormones, osteoporosis. (Mičuda, 3)
Antibacterial drugs - general pharm., beta-lactams, vancomycine, macrolides, aminoglycosides. (Mičuda, 3)
Antibacterial drugs - tetracyclines, sulfonamides, quinolones, other ATBs. (Mičuda, 2)
Anticancer drugs - general pharmacology and overview of drugs. (Chládek, 2)
Practical courses & seminars
Lecturers
Prof. Stanislav Mičuda, M.D., Ph.D.
Assoc. Prof. Martin Štěrba, PharmD., Ph.D.
Assoc. Prof. Jaroslav Chládek, MSc., Ph.D.
Jolana Schreiberová, M.D., Ph.D.
PharmDr. Olga Lenčová, Ph.D. 1. Drug dependence and abuse, revision of CNS pharmacology - microlesson and seminar. 1.1. General pharmacology of drug dependence, drugs and agents inducing dependence. 1.2. Revision of CNS affecting drugs related to the topics (esp. hypnosedatives and opioids). 1.3. Test (Moodle). 2. Drugs used in altered states of hemostasis (bleeding and thrombosis) - seminar.2.1. Basic and clinical pharmacology.2.2. Therapy of thrombosis and monitoring of therapy with anticoagulants.2.3. Test (Moodle). 3. Drugs acting on the gastrointestinal tract. Hypolipidemic drugs - microlesson and seminar. 3.1. Test (Moodle). 4. Antiasthmatics, histamin and antihistamines - microlesson and seminar. 4.1. Basic and clinical pharmacology. 4.2. Approach to asthma management. 4.3. Practical demonstrations: Handling different types of inhalers. 4.4. Test (Moodle). 5. CVS I: Cardiac glycosides, drugs affecting RAAS, diuretics - seminar. 5.1. Basic and clinical pharmacology.5.2. Test (Moodle). 6. CVS II: Overview of pharmacological treatment of angina, hypertension and heart failure - seminar. 6.1. Basic and clinical pharmacology. 6.2. Test (Moodle). 7. Pharmacology of hormones - insulin and antidiabetics, corticoids - microlesson and seminar. 7.1. Test (Moodle). 8. Antibiotics I - seminar. 8.1. Beta-lactams, aminoglykosides, glycopeptides, clindamycin, chloramphenicol, macrolides. 8.2. Test (Moodle). 9. Antibiotics II - seminar. 9.1. Quinolones, sulphonamides, urinary tract antiseptics, antimycobacterial and antifugal drugs. 9.2. Test (Moodle). 10. Anticancer chemotherapy - microlesson and seminar. 10.1. Basic pharmacology of cytostatics. 10.2. Test (Moodle). 11. Factors influencing the response to a drug. 11.1. depending on the drug: physico-chemical features, route of administration, drug formulation, food11.2. depending both on the drug and on the body: dose, repeated administration (accumulation, tolerance), coadministration with other drugs (synergism, antagonism), delayed effects 11.3. depending on the body: gender, age, genetic information, pathological state. 11.4. Demonstration: digoxin and lignocaine in kidney and liver failure. 11.5. Test (Moodle). 12. Basic information on pharmaceutical dosage forms, prescription writing - microlesson and seminar. 12.1. Test (Moodle) and credit.
Consultations with any teacher of the Department of Pharmacology are possible by prior arrangement.
Annotation
The teaching is a continuation of the subject Pharmacology I. and is focused on special chapters organized into topics grouped according to individual organ systems. Emphasis is placed on familiarization with the principles of clinical use of the drugs discussed. Specifically, it is an introduction to drugs used in the therapy of cardiovascular diseases, blood coagulation disorders, hyperlipidemia, diseases of the hormonal system, including the use of hormones in the role of drugs, metabolic diseases such as obesity and diabetes mellitus, diseases of the gastrointestinal tract, immune, infectious and cancer diseases. As part of the course, selected chapters on drugs affecting the central nervous system are repeated, and the issue of drug addiction is addressed. The superstructure area is then a set of factors that influence the body's reaction to the drug and condition the intra- and inter-individual variability of the body's response to standard treatment. In the end, chapters on dosage forms and drug prescriptions are discussed. Practical teaching is oriented towards the use of acquired knowledge to solve specific pharmacotherapeutic situations that can be observed in clinical practice.
Entry requirements: prerequisites: completed Pharmacology I.
Outcomes (subject Pharmacology II): 1. the student acquires theoretical knowledge of the special pharmacology of the organ systems being addressed, with emphasis on the practical use of drugs in specific clinical situations. 2. the student will acquire practical skills in prescribing drugs and evaluating the effect of drugs to optimize the results of therapy with the minimization of side effects. 3. the student will be able to identify drugs by name and describe their basic properties.