Syllabus
Lectures
Structure of the drug as the starting point for the determination of analytically usable physicochemical properties
Drug Identification
? Detection of drugs on the basis of physical constants (melting point, distillation range, density, refractive index, optical rotation)
? Use of physicochemical methods for the detection of drugs (spectral, separational, electrochemical methods)
? Detection of drugs by means of chemical reactions
? Group and selective reactions of individual structural types of drugs of important pharmacotherapeutic groups (analgesics-antipyretics, analgesics-anodynes, sedatives, anaesthetics, hypnotics, psychopharmaceuticals, analeptics, local anaesthetics, myorelaxants, adrenomimetics, adrenolytics, cholinomimetics, cholinolytics, antihistamines, cardiotonic glycosides, antihypertensives, vasodilators, laxatives, diuretics, vitamins, hormones, antimycotics, antimalarial agents, antibacterial sulfonamides, antibiotics, antiviral agents, anthelminthic agents)
The fundamentals of drug level monitoring
The principles of good laboratory practice ____
Practical Training
? Control-analytical evaluation of drugs according to the pharmacopoeia
? Identification of drugs by means of physical constants, chemical reactions, physicochemical methods
? Test for purity of drugs (chemical detection of impurities, detection of impurities, or degradation products by chromatographic and spectral methods)
? Determination of drug content (pharmacopoeial methods of quantitative evaluation of drugs)
Annotation
Drug control is one of the fundamental pharmaceutical disciplines. Theoretical and practical instruction aims to guarantee the quality, safety, and efficiency of drugs, which fulfils an irreplaceable principal function of a course in pharmacy.
Instruction includes not only the present editions of the Czech and European Pharmacopoeias but it is also based on other modern pharmacopoeia monographs, mainly the USP (United States Pharmacopoeia). The structure of the drug is the starting point for the determination of a suitable method for the identification.