Syllabus
Lectures Introduction History and development of the pharmaceutical industry, Good Manufacturing Practice, Technical documents in pharmaceutical industry - quality control system Chemical processes used in the syntheses of drugs: General reactions for: Oxidation (Oxidation of hydrocarbons, Oxidation of aromatic system, Oppenauer Oxidation) Reduction (Catalytic Hydrogenation, Béchamp Reduction, Clemmensen Reduction, Wolff-Kishner Reduction, Meerwein-Ponndorf-Verley Reduction) Condensation (Aldol Condensation, Perkin Reaction, Claisen-Smidt Condensation, Knoevenagel Condensation, Claisen Condensation, Dieckmann Reaction, Mannich Reaction) Addition (Addition on bond carbon-carbon, Diels-Alder Reaction, Michael Reaction, Addition on bonds carbon-oxygen and carbon-nitrogen) Polymeration and polycondensation Isomerization and rearrangement (Wagner-Meerwein Rearrangement, Wolff Rearrangement, Arndt-Eistert Synthesis, Benzilic Acid Rearrangement, Hofmann Reaction, Curtius Rearrangement, Schmidt Reaction) Special synthetic reactions for: Preparation of bond carbon-carbon (Friedel-Crafts Reaction, Gattermann Aldehyde Synthesis, Houben-Hoesch Reaction, Knorr Pyrazole Synthesis, Grignard Reaction, Reformatskii Reaction, Wurtz-Fittig Reaction, Blanc (Chloromethylation) Reaction) Preparation of bond carbon-hydrogen (Dehalogenation, Dehydroxylation, Deamination, Decarbonylation, Decarboxylation, Desulfonylation) Preparation of bond carbon-halogen (Halogenation, Finkelstein Reaction, Sandmeyer Reaction, Gattermann Reaction) Preparation of bond carbon-oxygen (Williamson Synthesis) Preparation of bond carbon-nitrogen Preparation of bond carbon-sulfur Practical Training Syntheses of representative types of drugs (Sulfanilamides, Benzocain, Clofibrat, Disulfiram, Etophyllin etc.). Excursion in a pharmaceutical manufacturing company.
Annotation
The lectures and practical training follow the subjects of Organic Chemistry II, Pharmaceutical Chemistry I and II. The students get acquainted with the theory and methodology of chemical processes which are important for the drug production.