Syllabus
Organic Chemistry I
Systematic nomenclature of organic compounds
Importance of Organic Chemistry in Pharmacy
Introduction to systematic nomenclature according to IUPAC
Saturated cyclic base components: bicycles, spirocycles, steroids
Unsaturated cyclic base components: monocyclic and orthofused aromates
Heterocyclic base components: Hantzsch-Widman system, orthofused heterocycles
Structure of organic compounds
Types of chemical bonds in organic compounds
Isomerism, constitutional isomers, stereoisomers
Chirality, enantiomers, diastereomers, descriptors R,S; D,L; E,Z
Conformations, conformational analysis
Polarity of bonds and related physical properties
Distribution of electron density in organic molecules
Inductive effect, resonance theory, mesomeric effect
Dipole moment, relative permitivity
Acidity and basicity in relationship to structure, basic terms.
O, S, N and C-acids
Attractive forces among molecules and related physical properties
Overview and importance of intermolecular attractive forces
Relationships between structure/melting points, boiling points and soulubility in water
Physical methods of structure elucidation
Introduction to molecular spectroscopy
UV and IR spectroscopy
NMR spectroscopy
Other methods: X-ray analysis, mass spectrometry
Annotation
Organic Chemistry I is a preparatory subject, focused on nomenclature and relationships between structure and physical properties of organic compounds, important for their application as chemical drugs. Emphasis is put on chemical drugs as small organic molecules, the properties and architecture of which determines transport in human organism and interaction with receptors. The subject thus enables the students to follow up in specialized pharmaceutical disciplines, primarily Pharmaceutical Chemistry, but also Pharmacognosy, Biochemistry and Pharmacology.
Topics: Nomenclature of Organic Compounds, Structure of Organic Compounds, Polarity of Bonds and Related Physical Properties, Intermolecular Attractive Forces and Related Physical Properties, Physical Methods of Structure Elucidation.