Syllabus
Diffusion
Fick's laws
Permeation through polymeric membranes
Aspects of diffusion within biological systems
Solubility of gases, liquids and solids
Dissolution and factors affecting it
Drug ionization
Dialysis and drug release
Solvents for solutions and other systems
Solutions colligative properties
Properties of solids
Crystallography
Polymorfy
Crystal hydrates
Surface properties of solid phase
Wettability of solid particles
Interparticular interactions
Interfacial phenomena liquid/liquid interphase, interfacial tension, factors affecting it
Liquid/gas interphase, surface tension, factors affecting it
Surface activity of compounds, surfactants
Structural types of surfactants
Reduction of surface and interfacial tension
HLB system
Solubilization
Micelles formulation, structural types of micelles, CMC
Disperse systems
Types of colloidal systems
Stability of colloidal systems
Pharmaceutical polymers
Polymeric systems structure, solubility, biodegradability
Gels
Application of polymers for pharmaceutical preparations
Stimuli-responsive polymers
Basics of pharmaceutical nanotechnology
Annotation
Subject Physical Principles of Dosage Forms is taught in the third year of study and builds on Biophysics and Physical Chemistry. The aim of the subject is to provide comprehensive information on the basic physical principles used in formulating and stabilizing pharmaceutical forms. In particular, it describes the properties of the solid phase (active compounds and Excipients), liquid phase and dispersion (molecular, colloidal and macrodispersion) and interfacial phenomena that are related to the physical and chemical stability of pharmaceutical products. In the subject of the Physical Principles of Dosage Forms, students will also be acquainted with the basics of polymer chemistry necessary to understand the structure, properties and function of these substances in pharmaceutical formulations and modern drug delivery systems. The basic principles of pharmaceutical nanotechnologies will also be included.
Considering that the physical properties of materials and physical processes at the interface significantly affect the resulting quality of pharmaceutical formulations, understanding these principles is essential for further study of pharmaceutical technology and dosage forms. From this perspective, the Physical Principles of Dosage Forms can be viewed as an interdisciplinary subject with a linking function between fundamental subjects taught in the first section of study and highly specialized pharmaceutical technology.
Topics: Solution properties, Solid-phase, Solid-phase properties, Solubility and dissolution, Diffusion, Interfacial phenomena in pharmaceutical Systems, Pharmaceutical surfactants, Pharmaceutical polymers, Polymer systems, Rheology, Dispersion systems and their stability, Nanotechnology.