Syllabus
General pharmacology
Pharmacokinetics
Types of drug transport across biological membranes
Absorption of drugs; factors influencing absorption
Distribution of drugs in organism; factors influencing distribution
Distribution - physiological barriers
Metabolism of drugs; factors influencing metabolism
Mechanisms of drugs excretion; factors influencing excretion
Basic pharmacokinetic parameters, calculation, practical significance in pharmacotherapy
Factors influencing pharmacokinetics
Pharmacodynamics
Mechanisms of drug actions
Quantitative (graded) and quantal (population) dose (concentration)-response relationships. Therapeutic index
Drug interactions
Adverse and toxic effects of drugs
Drug dependence, basic types
Preclinical testing of drugs
Clinical testing of drugs
Pharmacology and human genome (pharmacogenomics)
Special pharmacology
Pharmacology of the peripheral nervous system
Autonomic nervous system – muscarinic agonists (parasympathomimetics). Inhibitors of acetylcholinesterase (indirect cholinomimetics)
Autonomic nervous system – muscarinic antagonists (parasympatholytics)
Autonomic nervous system – adrenoceptor agonists (sympathomimetics)
Autonomic nervous system – adrenoceptor antagonists (sympatholytics)
Neuromuscular-blocking drugs
Local anaesthetics
Pharmacology of the kidneys
Diuretics
Pharmacology of the cardiovascular system (and risk factors)
Pharmacotherapy of dyslipidaemias
Vasoactive drugs; pharmacotherapy of arterial hypertension
Pharmacotherapy and prevention of ischaemic heart disease
Pharmacotherapy of heart failure
Pharmacotherapy of cardiac dysrhythmias
Pharmacology of the CNS (part I)
Pharmacotherapy of Parkinson´s disease
Current pharmacotherapy of Alzheimer´s disease
General anaesthetics
Vitamins
Overview, indications, toxicity
Annotation
Pharmacology is a scientific discipline studying the interactions of drugs with the organism both in the sense of pharmacokinetics (the fate of the drug in the organism) and pharmacodynamics (effect of drugs on the organism). These interactions are studied at all levels (molecular, cellular, organ, whole organisms). Pharmacology teaching in the “Pharmacy study program” is divided into two immediately adjacent parts: Pharmacology I (taught in winter semester of the 3rd year) and Pharmacology II (taught in summer semester of the 3rd year). Students will first learn about the general rules of pharmacokinetics (absorption, distribution, metabolism and excretion) and pharmacodynamics (mechanisms of drug effects, adverse reactions, principles of drug-drug interactions). Subsequently, topics of special pharmacology are discussed according to individual organ systems (e.g. cardiovascular, CNS, endocrine...). In the course of pharmacology, emphasis is also placed on the clinical aspects of drug effects in humans. The knowledge gained subsequently enables the pharmacist, in collaboration with a physician, to contribute to rational, safe and effective pharmacotherapy.
The subject of Pharmacology I focuses specifically on the following thematic areas: General pharmacology Pharmacokinetics Pharmacodynamics Special Pharmacology Pharmacology of the peripheral nervous system Pharmacology of the kidneys Pharmacology of the cardiovascular system (and risk factors) Pharmacology of the CNS (part I)