Syllabus
Biotransformation study of a model drug in vitro
Determination of specific activities of the selected aldo-keto reductases
Electrophoresis and immunodetection of microsomal proteins
Cytotoxicity test of selected drugs on the cell line
Overall evaluation of the results obtained
Annotation
Xenobiochemistry studies the metabolic transformations of substances that are foreign to organisms, especially drugs and environmental contaminants. In Practical Exercises in Xenobiochemistry, students will get acquainted with basic model systems and methods in the study of xenobiotic metabolism, biotransformation enzymes, and factors that affect the metabolism of xenobiotics.