Sylabus
Introduction into natural products, Classification of metabolites
Secondary metabolites of plants: Alkaloids I: introduction, basic classification, characterization and chemical properties of alkaloids
Secondary metabolites of plants: Alkaloids II – biosynthesis and biological activity
Secondary metabolites of plants: Alkaloids III -biosynthesis and biological activity
Secondary metabolites of plants: Alkaloids IV -biosynthesis and biological activity
Further groups of secondary metabolites from plants (glucosinolates, cyanogenic glycosides, betalaines, sulfur compounds etc.)
Secondary metabolites of plants: Polyketides: aliphatic (fats, oils, waxes), aromatic (anthraquinone and dianthrone derivatives). Phloroglucinol derivatives. Cannabinoids.
Secondary metabolites of plants: Shikimates: biogenesis, classification: phenylpropanoids, lignans, coumarins, benzoic acid derivatives, simple phenols, simple naphthoquinones
Secondary metabolites of plants: Shikimates with participation of the polyketide pathway: flavonoids, flavonolignans, tannins, arylalkanones, stilbenes, xanthones
Secondary metabolites of plants: Terpenoids I - substances derived from mevalonic acid, biogenesis: basic classification, monoterpenes, iridoids, sesquiterpenes
Secondary metabolites plants: Terpenoids II - substances derived from mevalonic acid: diterpenes, triterpenes, steroids, saponins, cardioactive glycosides, tetraterpenes, polyterpenes
Secondary fungal metabolites, Marine natural products I
Marine natural products II, Metabolites of animals,
Secondary metabolites as inspiration for medicinal chemistry
Anotace
Předmět seznamuje studenty s poznatky v oblasti léčiv přírodního původu (rostliny,mikroorganismy, živočišné produkty) a to z hlediska poznání chemické struktury účinných látek, jejich biosyntézy, možností jejich technologického získávání i terapeutického použití v humánní a veterinární medicíně. Získávají zde rovněž poznatky o zákonných normách a specifikách, které řídí jejich použití