Syllabus
Introduction into natural products, Classification of metabolites
Secondary metabolites of plants: Alkaloids I: introduction, basic classification, characterization and chemical properties of alkaloids
Secondary metabolites of plants: Alkaloids II – biosynthesis and biological activity
Secondary metabolites of plants: Alkaloids III - biosynthesis and biological activity
Secondary metabolites of plants: Alkaloids IV - biosynthesis and biological activity
Further groups of secondary metabolites from plants (glucosinolates, cyanogenic glycosides, betalaines, sulfur compounds etc.)
Secondary metabolites of plants: Polyketides: aliphatic (fats, oils, waxes), aromatic (anthraquinone and dianthrone derivatives). Phloroglucinol derivatives. Cannabinoids.
Secondary metabolites of plants: Shikimates: biogenesis, classification: phenylpropanoids, lignans, coumarins, benzoic acid derivatives, simple phenols, simple naphthoquinones
Secondary metabolites of plants: Shikimates with participation of the polyketide pathway: flavonoids, flavonolignans, tannins, arylalkanones, stilbenes, xanthones
Secondary metabolites of plants: Terpenoids I - substances derived from mevalonic acid, biogenesis: basic classification, monoterpenes, iridoids, sesquiterpenes
Secondary metabolites plants: Terpenoids II - substances derived from mevalonic acid: diterpenes, triterpenes, steroids, saponins, cardioactive glycosides, tetraterpenes, polyterpenes
Secondary fungal metabolites, Marine natural products I
Marine natural products II, Metabolites of animals,
Secondary metabolites as inspiration for medicinal chemistry
Annotation
The subject provides students with information about therapeutics of natural origin (plants, microorganisms, animals products) in the term of knowledge of chemical structures of active substances, their biosynthesis, possibilities of their technological obtaining as well as therapeutic applications in human and veterinary medicine.