Syllabus
Pathways of drug metabolism
Introduction, Phase I metabolism (oxidation, reduction, hydrolysis, hydration), Phase II metabolism (conjugation with sugars, sulfation, methylation, acetylation, amino acid conjugation, glutathione conjugation, fatty acid conjugation)
Enzymology and molecular mechanisms of drug metabolism reactions
Introduction, oxidases (cytochrome P450 superfamily, Flavin-containing monooxygenases), reductases (Aldo-keto reductase superfamily, SDR superfamily), transferases
Induction and inhibition of drug metabolism
Introduction, induction of drug metabolism in experimental animals and man, molecular mechanisms of induction, molecular mechanisms of inhibition
Factors affecting drug metabolism: Internal factors
Introduction, species differences, genetic differences, age, hormonal control of drug metabolism, the effect of disease
Factors affecting drug metabolism: External factors
Dietary factors, environmental factors
The clinical relevance of drug metabolism
Introduction, Pharmacokinetics, Methods for studying drug metabolism in man, clinical relevance of drug metabolism
Seminars
PowerPoint presentation of seminar work of students (one chosen clinically relevant enzyme for each student)
Annotation
Xenobiochemistry provides the basics necessary for understanding of xenobiotic metabolism, especially drugs and contaminants of environment. It explains the causes of the pharmacological and toxicological consequences of their presence in the living organism.
In the subject Xenobiochemistry, the students gain basic knowledge on the metabolism of xenobiotics in the organism, biotransformation enzymes and transport systems and factors influencing the metabolism of xenobiotics.