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Pharmacology I

Class at Faculty of Pharmacy in Hradec Králové |
GAPS339

Syllabus

General pharmacology

Pharmacokinetics

Types of drug transport across biological membranes

Absorption of drugs; factors influencing absorption

Distribution of drugs in organism; factors influencing distribution

Distribution - physiological barriers

Metabolism of drugs; factors influencing metabolism

Mechanisms of drugs excretion; factors influencing excretion

Basic pharmacokinetic parameters, calculation, practical significance in pharmacotherapy

Factors influencing pharmacokinetics

Pharmacodynamics

Mechanisms of drug actions

Quantitative (graded) and quantal (population) dose (concentration)-response relationships. Therapeutic index

Drug interactions

Adverse and toxic effects of drugs

Drug dependence, basic types

Preclinical testing of drugs

Clinical testing of drugs

Pharmacology and human genome (pharmacogenomics)  

Special pharmacology

Pharmacology of the peripheral nervous system

Autonomic nervous system – muscarinic agonists (parasympathomimetics). Inhibitors of acetylcholinesterase (indirect cholinomimetics)

Autonomic nervous system – muscarinic antagonists (parasympatholytics)

Autonomic nervous system – adrenoceptor agonists (sympathomimetics)

Autonomic nervous system – adrenoceptor antagonists (sympatholytics)

Neuromuscular-blocking drugs

Local anaesthetics

Pharmacology of the kidneys

Diuretics

Pharmacology of the cardiovascular system (and risk factors)

Pharmacotherapy of dyslipidaemias

Vasoactive drugs; pharmacotherapy of arterial hypertension

Pharmacotherapy and prevention of ischaemic heart disease

Pharmacotherapy of heart failure

Pharmacotherapy of cardiac dysrhythmias

Pharmacology of the CNS (part I)

Pharmacotherapy of Parkinson´s disease

Current pharmacotherapy of Alzheimer´s disease

General anaesthetics

Vitamins

Overview, indications, toxicity

Annotation

Pharmacology is a scientific discipline studying the interactions of drugs with the organism both in the sense of pharmacokinetics (the fate of the drug in the organism) and pharmacodynamics (effect of drugs on the organism). These interactions are studied at all levels (molecular, cellular, organ, whole organisms).

Pharmacology teaching in the “Pharmacy study program” is divided into two immediately adjacent parts: Pharmacology I (taught in winter semester of the 3rd year) and Pharmacology II (taught in summer semester of the 3rd year). Students will first learn about the general rules of pharmacokinetics (absorption, distribution, metabolism and excretion) and pharmacodynamics (mechanisms of drug effects, adverse reactions, principles of drug-drug interactions). Subsequently, topics of special pharmacology are discussed according to individual organ systems (e.g. cardiovascular, CNS, endocrine...). In the course of pharmacology, emphasis is also placed on the clinical aspects of drug effects in humans. The knowledge gained subsequently enables the pharmacist, in collaboration with a physician, to contribute to rational, safe and effective pharmacotherapy.

The subject of Pharmacology I focuses specifically on the following thematic areas:

General pharmacology

Pharmacokinetics

Pharmacodynamics

Special Pharmacology

Pharmacology of the peripheral nervous system

Pharmacology of the kidneys

Pharmacology of the cardiovascular system (and risk factors)

Pharmacology of the CNS (part I)