Syllabus
Definition and characterization of the subject Historical development of pharmaceutical chemistry Sources of new drugs Drug nomenclature Structural factors affecting biological activity Drug structure modifications Physicochemical properties in relation to biological activity
Practical classes concern various methods of drug study using physico-chemical approach (increase of water solubility, increase of lipid solubility, acidity, adsorption). Drugs are also studied from the stereochemical point of view using models of drugs.
Annotation
The subject Chemical Drugs employs the knowledge obtained in preceding subjects of science and medicinal character.
It affords complete overview about drugs and adjuvants of chemical character. It is an interdisciplinary subject connecting the chemical, biological and specific pharmaceutical disciplines. The subject includes historical aspects of drug development, sources, nomenclature and especially the aspects of chemical structure and its modifications influence on pharmaco-dynamic as well as pharmaco-kinetic processes in the course and after drug entry into body.