Syllabus
Lectures
Physics of radioactivity
Atom structure
Radioactive decay
Rules of radioactive conversions
Basis of radioactivity measurement
Gas-filled radioactivity detectors
Scintillation detectors
Instruments for in vivo counting and imaging
Production of radionuclides
Production in nuclear reactors
Production in cyclotrons
Radionuclide generators
Characteristics of radiopharmaceuticals
Definition of radiopharmaceuticals
Ideal characteristics of radiopharmaceuticals
Quality control of radiopharmaceuticals
Possibility of biologic testing
Physicochemical tests
Evaluation of radionuclide purity
Evaluation of radiochemical purity
Industrial production of radiopharmaceuticals
Primary medical radionuclides
Radiolabeled compounds for clinical use
Application of radionuclide generators
Kits for radiopharmaceutical preparations
Preparation of radiopharmaceuticals in hospitals
Ready-for-use radiopharmaceuticals
Radiopharmaceuticals prepared from kits
Radiopharmaceuticals prepared directly in relation to administration
Radiopharmaceuticals based on biological samples from patients
Technetium-99m radiopharmaceuticals
Indium-111radiopharmaceuticals
Short-living radiopharmaceuticals
Diagnostic applications of radiopharmaceuticals
Diagnostics of CNS disorders
Diagnostics of renal diseases
Diagnostic use of radiopharmaceuticals in cardiology
Lung imaging
Evaluation of liver functions
Diagnostics of bone pathologies
Evaluation of thyroid function
Imaging of cancer
Imaging of infection and inflammation
Therapeutic applications of radiopharmaceuticals
Treatment of myeloproliferative diseases
Treatment of thyroid disorders
Radiotherapy of arthritis
Palliative treatment of metastases
Use of radiolabeled monoclonal antibodies and receptor-specific peptides
Practical exercises
Measurement of radioactivity
Calculation of radioactive conversions
Work with radionuclide generator
Preparation of radiopharmaceuticals
Control of radiochemical and radionuclide purity
Excursion to department of nuclear medicine
Annotation
The aim of the subject is to apprise students theoretically and practically with preparation, control and clinical applications of radiopharmaceuticals. Attention is also paid to the use of radiolabeled compounds in research and other areas. A practical session aimed at preparation and radiochemical control of a model radiopharmaceutical is an important component of the subject. An excursion to department of nuclear medicine is also involved in the teaching.
Themes: Structure of atom, Decay schemes, Interaction of ionizing radiation with biological systems, Production of radiopharmaceuticals, Quality control of radiopharmaceuticals, Clinical applications of radiopharmaceuticals.