Sylabus
Lectures (L):
1. Physiology, pathology and pharmacology of trace elements (iron, copper and zinc)
2. Experimental determination of metal chelation, and metal based anti- or prooxidant properties
3. Physiology of blood coagulation and its testing
4. Cardiac toxicity
5. Intracellular receptors
6. Platelets, their structure, receptors, pathways and experimental results
7. Experimental testing of the effects of compounds on vascular smooth muscles – Practical lectures (PL):
1. Basic laboratory skills (weighting, pipetting, preparation of a calibration curve) – Mandatory
2. Screening of metal chelation activity
3. Screening of anticoagulant activity
4. Use of cell culture models for the study of toxic effects of drugs
5. Drug effects on intracellular receptors
6. Testing of potentially novel drugs at the platelet aggregation level
7. Testing of the effect of potentially novel drugs on the level of vascular smooth muscles