Syllabus
1. Introduction Into Antiviral Strategies - Principes of Viral Replication and Its Inhibition - Principles of Development of Antivirals - Current Status of Antiviral Therapy - General Antiviral Strategies - Antiviral Resistance
2. Development of Antiviral Compounds: The Case of Human Immunodeficiency Virus
3. Development of Antiviral Compounds: The Case of Hepatitis C Virus
4. Development of Antiviral Compounds: The Case of Hepatitis B Virus
5. Development of Antiviral Compounds: The Case of Influenza Virus and Coronaviruses
6. Development of Antiviral Compounds: The Case of Ebola, Dengue and Zika Viruses
7. Antiviral Agents Acting as DNA or RNA Chain Terminators
8. Viral Protease Inhibitors
9. Inhibitors of Viral Entry
10. Inhibitors of Viral Assembly
11. Nucleic Acid-Based Therapeutics
12. Antiviral Gene Therapy
Annotation
Antiviral Drug Discovery is an advanced course that brings a comprehensive overview of antiviral drugs approved over the past decades, focusing on research and development of effective antiviral treatment against current and emerging viruses such as HIV, HBV, HCV, HSV, HCMV, HPV, RSV, VZV, and influenza virus. The course is oriented primarily to the needs of biology and biomedical students at the upper undergraduate and advanced academic degrees (Master and Ph.D. candidates) who wish to expand their knowledge in antiviral drug discovery and medicinal chemistry.
The students will have the opportunity to learn what has been done to develop successful antiviral therapy, the drawbacks along the way and the tactical aspects of problem solving in antiviral drug design.