Syllabus
Syllabus "Structure and function of RNA"IntroductionRNA polymerase I transcriptsSynthesis and processing of ribosomal RNA, nuclear structure and function, structure and function of ribosomesRNA polymerase II transcripts- regulation of transcription by non-coding RNAs, links between transcription and processing- long non-coding RNAs, their transcription, processing and function of specific lncRNAs (XIST, HOTAIR, AIR, MALAT1, etc.)- short non-coding RNAs, snRNA and snoRNA biogenesis, scaRNA. telomerase structure and function- pre-mRNA processing (processing at 5' and 3' ends, editing, polyA), mRNA localization and stability- RNA splicing- regulation of alternative splicing- cellular structures involved in RNA metabolismRNA polymerase III transcriptsTranscription, processing and function of tRNA, 7SK, SRP, U6, RNA P and MRPCatalytic RNAsribozymes and ribosomes, spliceosome and ribosome as ribozymesRNAiSynthesis, processing and function of miRNA, piwiRNA, siRNATranslated with www.DeepL.com/Translator (free version)
Annotation
The course "RNA Structure and Function" is planned for master and PhD students and extends basic molecular and cell biology courses. The course is intended mainly for students who want to extend their knowledge about regulation of gene expression and about the ever-growing world of RNA.
Individual lectures are focused on transcripts of RNA polymerases I, II and II, their synthesis, processing and function. We will also discuss function of non-coding RNAs, riboswitches and ribozymes.
The majority of discoveries about RNAs is documented by original scientific publications with a description of key experiments.