Syllabus
Symmetrysymmetry operation, elements; point group, lattices, crystal systems, space group, basic crystallographic computing, International Tables of Crystallography A.
Reciprocal lattice
Sources of radiation for structural analysis, monochromatization, detectors
Interaction of X-ray with matter: fluorescence, emission, scattering.
Geometrical condition of diffraction: Bragg's law, Laue conditions, Ewald construction
Basic experimental method's: Laue method, Weissenberg camera, precession camera, Debye-Scherrer camera, diffractometers,
Kinematic theory of diffraction: Thomson scattering, scattering by atom, scattering by unit cell, diffraction on small crystal, LP-factor, temperature factor.
Structure factor, symmetry in reciprocal space, Fourier methods
Solution and refinement of crystal structure solution of phase problem: heavy atom method, isomorphous replacement method, anomalous scattering; direct methods completing and refining structure: difference Fourier method, refinement in direct and reciprocal space.
Basic of dynamical diffraction theory
Structure of polycrystalline materials: qualitative and quantitative phase analysis
Crystallographic databases: CSD, ICSD, PDF.
Introduction to proteins crystallography
Aperiodic crystals.
Selected physical properties of crystal.
Annotation
The aim of the course is to lay foundation in the key areas of X-Ray crystallography. The lectures with accompany seminaries are covering following areas on basic level: crystal symmetry, kinematic theory of diffraction, experimental techniques in powder and monocrystal diffraction, crystal structure solution of small molecules, qualitative and quantitative phase analysis, crystallographic databases, aperiodic crystals, selected physical properties of crystals.
This course is part of master's degree cycle.