Syllabus
1) Fundamentals of Inorganic Solution Chemistry Formal oxidation states and coordination geometries biologically important metal ions Stability constants, stabilization of oxidation states, kinetics and mechanizm of reactions involving metal complexes. Electron transfer reactions.
2) Transport and storage Metal ion uptake and transmembrane ion transport. Transport and storage of metals ions in vivo.
3) Oxygen Carriers Myoglobin and hemoglobin. Hemerythrin, hemocyanin.
4) Hydrolases Hydrolase enzymes, carboxypeptidase A, phosphatases, hydro-lyasa enzymes – acotinase.
5) Metalloproteins and Metalloenzymes – Redox Chemistry Cofactors and coenzymes in metaloredox proteins. Iron-sulfur clusters, hemes, copper ion and its complexes, molybdenum, cobalamins, nickel coenzymes. Mitochondrial electron transport. Photosynthesis.
6) Alkali and Alkaline Earth Metals. Overview of biological chemistry of group I and II. Enzyme activation, complexes with nucleic acids, biominerales, skeletal mass.
7) Toxicity and Chemoterapeutics. Oxygen toxicity, peroxidase, metal toxicity. Coordination complexes as therapeutic agents.
8) Metal complexes in medical imaging techniques and radiotherapy. Magnetic resonance imaging, radiodiagnostics, radiotherapy, production and application of metal radioisotopes, contrast agents for X-ray an luminescence imaging. References: Cowan J.A., Inorganic Biochemistry, VCH Publishers 1993, Lippard S.J. ed, Progress in Inorganic Chemistry: Bioinorganic Chemistry, 38,
1990.
Annotation
Fundamentals of inorganic solution chemistry. Transport and storage of metals ions in vivo. Metalloproteins and metalloenzymes - oxygen carriers, hydrolases, redox chemistry. Alkali and alkaline earth metals. Metals in the regulation of biochemical events. Cell toxicity and chemoterapeutics. Metal complexes in medical imaging methods and radiotherapy.
The course is designed for Master and PhD students.