Syllabus
Definition of molecular biology. History of molecular biology.
Structure and function of nucleic acids. Molecular structure of genes and chromosomes.
Protein structure and function. Protein complexes, self-assembly.
Molecular motors. DNA replication, recombination and repair.
Regulation of cell cycle. Apoptosis.
Transcription in prokaryotes and eukaryotes. Regulation of transcription.
Translation. Structure of the ribosome.
Protein channel. Insertion of proteins into plasmatic membranes.
Intracellular transport, folding and posttranslational modifications of proteins. Membrane transport.
Most important cellular signaling cascades. Gene control in development.
Hox genes in Drosophila and other organisms. Integration of cells into tissues.
Cell adhesion molecules.
Annotation
!!! N.B. LECTURES ARE DELIVERED IN CZECH LANGUAGE. EXAMINATION POSSIBLE IN CZECH OR ENGLISH. Basic course of molecular biology deals primarily with two most important classes of biological macromolecules - nucleic acids and proteins. Static aspects involve discussion of the structure of macromolecules and their complexes (DNA binding proteins, protein complexes, molecular motors). Dynamic aspects include classical chapters on DNA replication, transcription, translation, folding and posttranslational modifications of proteins, and their cellular transport. Molecular mechanisms underlying selected cellular processes such as regulation of the cell cycle, apoptosis, membrane transport, cellular signaling and integration of cells into tissues and organs are also covered.
Lectures - in Czech -
Webinar at https://cesnet.zoom.us/j/93871874724?pwd=Y0NKRk5lYzVEM3NSdlJIdTA0d1Yzdz09