Syllabus
PART I - development of new drugs and treatments
1. Cytostatics (treatment of oncological diseases, carcinogenesis)
2. Introduction to immunotherapy (treatment of oncological diseases, allergies and autoimmune diseases)
3. Gene therapy (treatment of genetic diseases, viral and oncological diseases)
4. Influence of diet on health and diseases (essential components of diet, obesity - cardiovascular diseases, ketosis)
5. Development of new drugs (goals of pharmaceutical intervention, three phases of clinical testing) - prof. Konvalinka
6. Antivirals (AIDS drugs, COVID-19, ZIKA, EBOLA…) - prof. Konvalinka PART II - laboratory examination (diagnostics) - methods and biochemical markers of pathological conditions
7. Laboratory diagnostics, tumor markers (carcinogenesis)
8. Cardiomarkers (atherosclerosis)
9. Methods in laboratory tests (including different approaches for virus detection)
10. Reliability of laboratory diagnostics results (diagnostic sensitivity and specificity)
Annotation
Lectures - in Czech -
The first part of the lectures will be devoted to the development of new drugs and treatments. We will focus on the knowledge of intermediate metabolism as a tool for the regulation of pathological processes in the organism. We will also focus on the biochemistry of civilization diseases and the metabolism and biochemical nature of the effect of drugs. Last but not least, emphasis will be placed on understanding the principles of drug design based on intervention in key biochemical processes in the body.
In the second part of the course we will focus on the second part of biomedicine on advances in laboratory diagnosis of pathological conditions, including the methodology and biochemical nature of laboratory tests and examinations.