Syllabus
1. Basic principles of ss-NMR spectroscopy and historical overview The first lecture is devoted to the basic principles of ss-NMR spectroscopy. These principles are discussed in the context of historical milestones.
2. Architecture of liquisolid systems and invisible (dark) matter in ss-NMR The second lecture is focused on a very interesting aspect of liquisolid systems, their structure, architecture, formation of exotic phases. In this regard the basic experimental techniques, their selectivity and limitations will be again discussed. This is also perfect occasion to open the discussion of the invisible matter in solid state.
3. Structural diversity of solid dispersions: structure, morphology and phase-transitions In the third lecture the structural diversity of solid dispersions and other multicomponent solids is discussed.
4. Polymorphism of pharmaceutical solids: NMR crystallography Polymorphism of pharmaceutical solids, crystalline active pharmaceutical ingredients and introduction to NMR crystallography is the topic of the fourth lecture.
5. Crystal structure predictions and domain-edited NMR crystallography In the fifth lecture we will continue with the discussion of NMR crystallography. Specifically, we will talk about the crystal structure prediction, their experimental verification, and application of NMR crystallography on multicomponent and polycrystalline mixtures.
6. A story about an unknown structure of a well-known ss-NMR model compound The true potential of NMR crystallography in the ab-initio, de-nuovo, determination of crystal structure will be demonstrated on an f-MLF tripeptide, whose structure has not yet been determined. You will be among the first to see it.
7. What about quadrupolar nuclei? Structural diversity of boronic acid derivatives. In the subsequent lecture we will turn our attention to quadrupolar nuclei, specifically, to boron-11. In this regard we will discuss dynamic self-assemble processes of derivatives of boronic acid.
8. Amorphous solids and principal component analysis Amorphous phase. The structure of amorphous phase is a bit mysterious. One of the possible insights into the structure of amorphous phase can be obtained through the principal component analysis of NMR spectra. And particularly this analysis is a subject of the eighth lecture.
9. Conductivity and transferring Li+ ions in solid state Going gradually to the end of the course we will open the question of the dynamics, transfer and local mobility of Li ions in polymer matrices and framework materials – potential all-solid-state electrolytes.
10. Frameworks, networks and crosslinks One of the last lectures will be devoted to the structure of metal-organic frameworks, polymer networks and their cross-links.
11. Summary: challenges, potentials and limitations of ss-NMR The last lecture will summarize all the previous presentations and show potentialities, limitations and challenges of advanced solid-state NMR spectroscopy.
Annotation
This course introduces to students not only the basic principles of solid-state NMR spectroscopy, but also presents the current trends that allow for a detailed analysis of the structure and dynamics of condensed matter. The course is focused on the application of advanced NMR spectroscopy techniques for assessing the structure and dynamics of various multi-component nanostructured systems with hierarchically defined architecture.
The basic principles of these techniques are discussed in the introductory parts of the lectures. Experimental procedures are then always demonstrated on typical examples, with the greatest attention being paid to interpretations of experimental data.
Step-by-step, polymer composites and nanocomposites, pharmaceutical systems, polymeric nanoparticles and microparticles, liquid-crystalline and liquisolid systems, organogels and framework materials are investigated, spectroscopically decomposed on individual components and their structures thoroughly discussed. Considerable attention is paid to both collective processes and structural defects and the possibilities of their identification.
Courses is held in English or Czech.