Sylabus
The course is designed for students of organic chemistry of the first year of master study to deepen their skills and independence in organic synthesis. The task is to perform a four to five step synthesis of an organic compound, conducted in collaboration with research groups within and outside the Department of Organic Chemistry, which provides a link with modern research and methods. Students are assigned with a synthetic task in an area which is different from their ongoing master’s and finished bachelor’s projects. Before the synthesis begins, the student shall independently carry out a literature search for the given target compound, propose their own synthetic route and discuss their findings and proposal with an authorized person. Searching in chemical reaction databases (SciFinder® and Reaxys®) and subsequent retrieval of related primary scientific documents from online sources is mandatory forepart of the practice. All the prepared compounds must be characterized by using spectroscopic methods (NMR, MS).
Tasks are changed annually.
Expected learning outcomes
After successful completing of this course, students should be able to:
- conduct basic retrosynthetic analyses.
- search and find relevant information using available sources.
- independently design multistep syntheses and choose suitable experimental procedures according to the literature.
- use modern spectroscopic methods for structure determination.
- apply knowledge of organic reaction mechanisms to investigate and determine reaction outcomes.
- conscientiously document experimental procedures and spectral data.
Anotace
The main goal of this course is to cultivate independence in the design, and safe, economical and ecological implementation of multistep organic syntheses to achieve a stated objective. Supporting this are many other goals including conscientious recordkeeping and appropriate handling of spectral data.
New experimental techniques can be introduced including macro-scale synthesis, microwave assisted synthesis or the work with air-sensitive compounds. Finding relevant information using chemical reaction databases (SciFinder® and Reaxys®) is also an integral part of the course.