Sylabus
Notice: Individual subchapters might be subject to change. 1.Introduction 1.1. Basic Principles 1.2.
Pathways for the Formation of Organo-Transition Metal Species 1.3. Transmetallation and Ligand Transfer 2.
Electronic and Steric Ligand Effects in Transition Metal-Catalyzed Reactions (Mainly Phosphorus Ligands) 2.1. Introduction and Definitions (Steric and Electronic Effects) 2.2.
Ligand Effect on Oxidative Addition/Reductive Elimination (General Guidelines) 2.3. Some Typical Examples of Ligand Effects 2.4.
Influence of Electronic Tuning on Enantioselectivity 2.5. Bite Angle 2.6.
Some Typical Examples of Influence of Bite Angle 3. Cross-Coupling Reactions 3.1.
Introduction 3.2. Negishi Coupling 3.3.
Kumada-Tamao Coupling 3.4. Sonogashira Coupling 3.5.
Stille Coupling 3.6. Suzuki Coupling 3.7.
Reactivity of Trans and Cis Vinyl Halides. 3.8. Glaser and Chodkiewicz-Cadiot Coupling 3.9.
Other Cross-Coupling Reactions (coupling between sp3 and sp3 carbons) 3.10. Nozaki-Hiyama-Kishi coupling 4. [2+2+2]-Cycloaddition Reactions 4.1.
Introduction 4.2. Intermolecular Cyclotrimerization 4.3.
Co-cyclotrimerization of Diynes and Alkynes 4.4. Intramolecular Cyclotrimerization of Triynes 4.5.
Cyclotrimerization of Two Alkynes and a Nitrile 4.6. Cyclotrimerization of Diynes and a Nitrile 4.7.
Cyclotrimerization of Alkynes with Other Unsaturated Compounds 5. Other Cycloadditions 5.1.
Introduction 5.2. [2+1] Cycloadditions 5.3. [2+2] Cycloadditions 5.4. [3+2] Cycloadditions 5.5. [3+3] Cycloadditions 5.6. [4+1] Cycloadditions 5.7. [4+2] Cycloadditions 5.8. [4+3] Cycloadditions 5.9. [4+4] Cycloadditions 5.10. [5+n] Cycloadditions (n = 1, 2) 5.11. [6+2] Cycloadditions 5.12. [2+2+1] Cycloadditions 5.13. Other [2+2+2] Cycloadditions 5.14. [4+2+2] Cycloadditions 5.15. [2+2+2+2] Cycloadditions 5.16. [4+4+1] Cycloadditions 6.
C-H Bond Activation 6.1. Introduction 6.2.
Dehydrogenation 6.3. Formation of Carbon-Carbon Bonds via CO and Isonitrile Insertion 6.4.
Formation of Carbon-Carbon Bonds via Alkene and Alkyne Insertion into Unsupported C-H bonds 6.4.1. Hydroarylation, etc. 6.4.2.
Hydroacylation 6.5. Formation of Carbon-Carbon Bonds via Alkene and Alkyne Insertion into Potentially Chelating Systems 6.6.
Cascade Alkene Insertion into Unsupported C-H bonds and Potentially Chelating System 6.7. Activation of Acidic C-H bonds in Alkynes 6.8.
Activation of Acidic C-H bonds in Carbonyl and Related Compounds 7. Carbon-Carbon Bond Activation 7.1.
Introduction 7.2. Alkene-Alkene Ring Closing Metathesis 7.3.
Enyne Metathesis 7.4. Flexibility of Alkene-Alkene and Alkene-Alkyne Metathesis in Organic Synthesis 7.5.
Diyne Metathesis 7.6. Small Ring Cleavage 7.6.1.
Cleavage of Simple Cyclopropanes 7.6.2. Cleavage of Alkylidenecyclopropanes 7.6.3.
Cleavage of Vinylcyclopropanes 7.6.4. Cleavage of Cyclobutanes 7.6.5.
Cleavage of Cyclobutanones 7.6.6. Cleavage of Cyclobutenones and Cyclobutenediones 7.7.
Other Transition Metal Catalyzed Carbon-Carbon Bond Cleavage Reactions 7.8. Transition-Metal Catalyzed Rearrangements 7.9.
Carbon-Carbon Bond Cleavage in Organometallic Compounds of Early Transition Metals Metallacycles 8. Conjugate additions 8.1.
Introduction 8.2. Terminology and Classifications 8.3.
Additions of Stabilized Carbanions and Other Nucleophiles 8.4. Additions of Non-stabilized Carbanions (Organocopper, -nickel, etc) 8.5.
Conjugate Additions Catalyzed by Transition Metals 9. Transition Metal Catalyzed Cyclizations 9.1.
Introduction 9.2. Cyclization via Metallacycle intermediate 9.3.
Cyclization via Hydrometallation 9.4. Cyclization via Activation of C-H bonds 9.5.
Cyclizations via Oxidative additions 9.6. Radical Cyclization (Halotropic Cyclizations) 9.7.
Lewis acid Catalyzed Cyclizations 10. Double and triple bond functionalization 10.1.
Introduction 10.2. Heck Reaction 10.3.
Other Double Bond Functionalization 10.4. Triple Bond Functionalization 11.
Application of Catalysis in Organic Synthesis
Anotace
Clasification of organometalic compounds, their preparation and properties. Basic formalism of organometalic reactions, reaction mechaninisms.
Reactions catalyzed or mediated by transition metal complexes: cross-coupling reactions, cycloaddition reactions, conjugated additions, activation of C-H and C-C bonds, functionalization of C-C double and triple bonds.