Syllabus
Syllabus Organic Synthesis II
1. Cycloaddition reactions - Diels-Alder reaction: regioselectivity and stereoselectivity
2. Cycloaddition reactions - Dipolar cycloaddition: ozonolysis, cycloaddition of azides, diazo compounds, azomethinylides, [2 + 2] -cycloaddition
3. Organolithic, organomagnesium and organozinc compounds - preparation and reactivity
4. Organocuprates and organotin compounds - preparation and use
5. Sigmatropic rearrangements
6. Acids and bases catalyzed by rearrangements
7. Nominal reactions
8. Coupling reactions
9. Protecting groups - protection of alcohols, amines, etc.
10. Retrosynthetic analysis - synthons, synthetic equivalents, C-X disconnection
11. Retrosynthesis - C-C disconnection, multiple C-C disconnections
Annotation
Cycloaddition reactions, sigmatropic rearrangements, acid-promoted and base-promoted rearrangements, reactions of organometalic compounds (Grignard reagents, organocuprates, RLi, zinc reagents,etc.), Pd C-C and C-N coupling reactions, protective groups, named reactions. Retrosynthesis.
This course is for ERASMUS students also available in English.