Syllabus
1. Definition and clasification 1. Radiodiagnostics in vitro : RIA and similar methods 2. Radiodiagnostics in vivo : basic principles and methods scintigraphy, SPECT, PET 3. Radiotherapeuticals 2. Radionuclides, their selection and preparation 1. Neutron activation in nuclear reactor 2. Production of radionuclides in cyclotron 3. Radionuklide generators 3. Chemical forms 1. Simple inorganic compounds 2. Labelled organic compounds 3. Metal complexes with organic ligands
- complexes of technetium and rhenium
- complexes of indium
- complexes of other metals 4. Biologic macromolecules
- peptides and proteins
- monoclonal antibodies and their fragments
- oligonucleotides 5. Cells (blood cells) 6. Agregates 7. Colloids 4. Scintigraphic investigation in nuclear medicine 1. Principles of tomographic imaging 2. SPECT (Single Photonon Emission Computer Tomography) 3. PET (Positronium Emission Tomography) 4. Hybrid systems 5. Radiopharmaceuticals (testing, storage, forms, etc) 6. Biological effects of radiation (protection, waste tretment, etc) 5. Instrumentation and pharmakology in nuclear medicine 1. Detection of radiation (screening, collimation, detectors, registration, errors) 2. Analogous and digital imaging 3. Methods of registration 4. Imaging methods in nuclear medicine 5. Computational processing of scintigraphic pictures 6. Fundamentals of pharmakology (application, pharmacokinetics, organ distribution, interaction, undesirable effects) 6. Nuclear cardiology 1. Physiology and pathophysiology of heart 2. Equilibrium ventriculography 3. Perfussion angiocardiography 4. Heart muscle blood supplying investigation 5. Heart necrosis imaging methods 6. Viable myocard proving methods 7. Receptor diagnostics 8. PET investigation of myocard 7. Nuclear neurology 1. Fundamentals of brain physiology and pathophysiology 2. Blood flow through brain 3. Metabolic studies with PET 4. Dammage of blood-brain barrier 5. Receptor diagnostics 6. Scintigraphy of liquor spaces 8. Nuclear nefrology 1. Fundamentals of kidney physiology and pathophysiology 2. Clearence methods 3. Dynamic scintigraphy 4. Static scintigraphy of kidneys 5. Isotope nefrography 6. Radioisotope cystography and uroflowmetry 9. Nuclear oncology 1. Fundamentals of tumor physiology and pathophysiology 2. Tumor markers 3. Labelled peptides 4. Tumor scintigraphy 5. Thyroid bladder tumor therapy 6. Palliative treatment of bone metastases 10. Nuclear orthopedy, bone marrow and hematology in scint. picture 1. Fundamentals of bones and blood physiology and pathophysiology 2. Kinds of skeletal imaging (local, whole body, SPECT, three phase scintigraphy) 3. Investigation of bone marrow distribution 4. Scintigraphy of spleen 5. Survival of erythrocytes (incl. localization of destruction) 6. Determination of blood flow kinetics and blood volume 11. Other investigation methods in nuclear medicine 1. Diagnostics in pneumology 2. Diagnostics of digestive tract diseases 3. Diagnostics of inflammations and lymfatic system 4. Diagnostics of arterial and venal system 5. Diagnostics in endocrinology
Annotation
The basic principles of nuclear chemistry. A survey of radionuclides used in nuclear medicine.
The common methods of radiopharmaceuticals preparations. Quality and control of radiopharmaceuticals.The basic radiopharmaceuticals and their use in human diagnostic and therapy.