Syllabus
* Concepts Definition and Development of Supramolecular Chemistry Classification of Supramolecular Host-Guest Compounds Receptors, Coordination and the Lock and Key Analogy Chelate and Macrocyclic Effects Preorganisation and Complementarity Thermodynamic and Kinetic Selectivity Nature of Supramolecular Interactions Supramolecular Host Design
* Supramolecular Chemistry of Life Alkali Metal Cations in Biochemistry Porphyrins and Tetrapyrrole Macrocycles Supramolecular Features of Plant Photosynthesis Uptake and Transport of Oxygen by Hemoglobin Coenzyme B12 Neurotransmitters and Hormones DNA Biochemical Self-Assembly * Cation-Binding Hosts Crown Ethers Lariat Ethers and Podands Cryptands Spherands Nomenclature Solution Behavior Selectivity of Cation Complexation Macrocyclic, Macrobicyclic and Template Effects Preorganisation and Complementarity Soft Ligands for Soft Metal Ions Complexation of Organic Cations Alkalides and Electrides Calixarenes Carbon Donor and ?-acid Ligands Siderophores
* Binding of Anions Biological Anion Receptors Concepts in Anion Host Design From Cation Hosts to Anion Hosts - a Simple Change in pH Guanidinium-Based Receptors Organometallic Receptors Neutral Receptors Hydride Sponge and Other Lewis Acid Chelates Anticrowns Coordination Interactions
* Binding of Neutral Molecules Inorganic Solid-State Clathrate Compounds Solid-State Clathrates of Organic Hosts (urea clathrates, cyclotriveratrylene, tetraphenylene) Intracavity Complexes of Neutral Molecules: Solution and Solid-State Binding (cyclodextrins, cryptophanes, carcerands)
Annotation
The lecture explains basic concepts of supramolecular chemistry, informs about the most important families of compounds, which belong there, about their synthesis or occurrence in nature, methods of their design and practical use. The concepts to be explained are: receptor, coordination, lock and key, host and guest, chelate, macrocyclic and template effects, preorganisation, complementarity, self-assembly.
Hosts of cations, anions and neutral molecules will be presented (crown-ethers, podands, cryptands, spherands, calixarenes, zeolites, cyclodextrins, cryptophanes, carcerands).