Syllabus
* I. BASIS OF ORGANIC CHEMISTRY
- chemical bond, organic nomenclature, reactions in organic chemistry, hydrocarbons, hydrocarbon derivatives, important heterocycles)
- water properties
* II. SACCHARIDES AND GLYKOBIOLOGY
- monosaccharides and disaccharides
- oligosaccharides and polysaccharides
- glycoconjugates (proteoglycans, glycoproteins, glycolipids)
* III. LIPIDS, BIOMEMBRANES AND TRANSPORT
- definition, nomenclature, chemical properties and reactions
- fatty acids
- storage lipids - triacylglycerols (fat vs. oil), waxes
- membrane lipids - phospholipids, sphingolipids, galactolipids and sulpholipids
- eikosanoids (prostaglandins, leukotriens, thromboxans)
- isoprenoids - terpenoids and steroids
* IV. NUCLEOTIDES AND NUCLEIC ACIDS
- bases, nucleosides, nucleotides and nucleic acides
- bases - tautomery, pK
- nucleic acid structure
- nucleic acid chemistry
* V. AMINO ACIDS, PEPTIDES AND PROTEINS
- amino acids
- peptides, peptide bond
- proteins
- 3D structure of proteins (primary, secondary, tertiary and quaternary structure of proteins)
- denaturation and protein folding
* VI. ENZYMES AND CATALYSIS
- enzyme function, enzymatic reactions
- enzyme kinetice, inhibition
- allostery, allosteric enzymes
- coenzymes, cofactors and prosthetic groups
- vitamins
Annotation
Principles of biochemistry - structure and properties of important metabolites (saccharides, proteins, lipids, nucleic acids and nucleotides), enzyme catalysis.