Syllabus
Basic characteristics of radiobiological mechanism in cells and tissues. Attempts of modeling it mathematically in the past century.
Survival curves and factors influencing radiobiological mechanism; especially oxygen enhancement ratio. Individual phases of the given mechanism: physical, chemical and biological; and corresponding model chain.
Microdosimetric characteristics and radiation energy transfer to the medium; influence of different radiomodificators; final radiobiological effect (cell inactivation and other consequences). Cumulative effect in the irradiated tissue; radiotherapy of tumors.
Radiobiological mechanism in cells; double-strand breaks of chromosomal DNA. Detailed shape of survival curves; importance for optimization of radiotherapy approaches and radiation hygiene (including protection of astronauts).
Application of different kinds of ionizing particles in tumor radiotherapy; hadrontherapy.
Annotation
The characteristics of individual phases of radiobiological mechanism in cells, the description of models. The model chain, inactivation effects, the survival curve.
The meaning of given models for the optimization of radiotherapy in treatment of cancer diseases and for the radiation hygiene.