Seminars – winter semester:

1. Introduction to pharmacology, basic terminology, and definitions. Regulatory authorities. Pharmacopeias. General principles of drug prescribing. Prescribing an RMP. Drug databases. Medication list.
2. Basics of IPP prescriptions. Routes of drug administration. Introduction to dosage forms. Liquid DF. Dispersions, semi-solid DF.
3. Solid dosage forms, 2nd, and 3rd generation of DF. Incompatibilities. Drug research and development.
4. Adverse drug effects. Pharmacovigilance. Drug allergy, anaphylactic shock. Carcinogenic and mutagenic effects.
5. Drugs in specific periods of life. Disorders of elimination organs.
6. Treatment of pain. Treatment of migraine.
7. Total repetition. Credit test.

Lectures – winter semester:

1. Pharmacodynamics – specific and non-specific mechanisms of drug acting; drug-receptor interactions.
2. Pharmacokinetics – mechanisms of drug permeation through biological membranes, basic pharmacokinetic processes, and parameters. Absorption.
3. Pharmacokinetics – distribution and drug metabolism.
4. Pharmacokinetics – excretion of drugs. Elimination by first order kinetics and by zero order kinetics, pharmacokinetic parameters of elimination and their significance.
5. Pharmacokinetic parameters for overall drug exposure and dosing, single and continuous drug administration.
6. Individualization of pharmacotherapy: pharmacogenetics, gene therapy. Biological treatment.
7. Chemical mediators and autonomic nervous system – sympathetic.
8. Autonomic nervous system – parasympathetic.
9. Chemical mediators.
10. Treatment of pain.
11. Treatment of migraine and antiepileptic drugs.
12. Psychiatric drugs.
13. Central and peripheral muscle relaxants. General and local anesthetics.