Lectures

Lecture

1^st Principles of immune system function (Krejsek)

2^nd Innate immunity, basic characteristics (Malá)

3^rd Specific immunity (Soucek)

TcR, BcR receptors
gene rearrangement
clonal selection hypothesis of specific immune response
T cells differentiation
HLA system, processing and presentation of antigenic fragments to T cells
polarisation of T cells, Th1, Th2, Th17, Treg subsets of T cells
B cells differentiation, antigen independent differentiation
B cell differentiation after antigenic stimulation, isotypic switching, somatic mutation
antibodies, molecular characteristics, dynamics of antibody production
immune memory

4^th Mucosal and skin immunity (Kolackova)

5^th Protective inflammation/damaging inflammation (Malá)

6^th Immunodeficiencie (Kralickova)

7^th Cancer and inflammatory response, immunomodulation (Soucek)

Lectures

Seminars and Practicals

1^st Allergic inflammation (Kralickova)

pathophysiology of allergic inflammation
allergens, components of allergens
allergic diseases, asthma, rhinitis, eczema …, clinical presentation
diagnosis of allergic diseases, skin tests, allergen specific IgE, basophil activation test in vitro

2^nd Prevention and treatment of allergic inflammation and anaphylaxis (Kralickova)

3^rd Immune deficiencies (Kralickova)

4^th Immunopathology, autoimmunity (Jankovicova)

immunopathology, initiation, pathophysiological mechanisms, hypersensitivity reactions
immunopathogenesis of selective autoimmune diseases (rheumatoid arthritis, systemic lupus, Crohn disease, celiac disease)
systemic and organ specific immunopathological diseases
autoantibodies and other biomarkers in differential diagnosis of immunopathological diseases

5^thCell mediated immunity (Soucek)

6^th Immunological detection of infectious agents (Rezacova)

direct evidence of infection
indirect evidence of infection
detection of specific antibodies as indirect evidence of infection
detection of specific cell-mediated immune response as indirect evidence of infection (IGRA tests)
immunological diagnosis of B. pertussis, B. burgdorferi, T. pallidum and M. tuberculosis infections
clinical interpretation of serological tests