The syllabus:

Lesson I

Gastrointestinal diseases of infectious origin

Pathophysiology of gastrointestinal diseases (osmotic, inflammatory, secretory mechanisms of diarrhoea)

Incidence and epidemiology of infectious gastroenterites

Infectious gastroenteritis of viral and bacterial origin and foodborne toxigenic diarrhoea (clinical course, diagnosis, therapy, prophylaxis)

Differential diagnosis of infectious and non- infectious diarrhoea

Complications of infectious diarrheal diseases

Clinical picture, epidemiology, pathophysiology, complications, therapy, prophylaxis of Salmonellosis, Salmonella typhi and paratyphi, Cholera, E.coli gastroenteritis, Campylobacteriosis, Yersinia enterocolitica, Shigellosis, pseudomembranous enterocolitis, Rotavirus, Adenovirus, Norwalk virus gastroenterites and other viral gastroenterites, foodborne toxigenic diarrhea

Hemolytic-uremic syndrome

Aspects of prophylaxis of infectious diarrhea (vaccination)

Lesson II

Infectious inflammatory diseases of the liver

Pathophysiology of viral hepatites

Incidence and epidemiology of viral hepatites

Acute viral hepatitis A - pathophysiology, epidemiology, clinical course, diagnosis (laboratory and serologic markers), therapy, prophylaxis specific and non-specific

Acute viral hepatitis B - pathophysiology, epidemiology, clinical course, diagnosis (laboratory and serologic markers), therapy, prophylaxis specific and non-specific

Acute viral hepatitis C - pathophysiology, epidemiology, clinical course, diagnosis (laboratory and serologic markers) therapy, possibility of prophylaxis

Viral hepatitis D - pathophysiology, epidemiology, clinical course, diagnosis (laboratory and serologic markers), therapy, possibility of prophylaxis

Acute viral hepatitis E- pathophysiology, epidemiology, clinical course, diagnosis (laboratory and serologic markers) , therapy, prophylaxis

Viral hepatites G, F, TTV - new causes of viral hepatites?

Complications and sequelae of acute viral hepatites

Differential diagnosis of acute hepatites (infectious and non-infectious origin)

Chronic hepatitites B and C - incidence, clinical picture, laboratory and serologic markers,

possibility of therapy and prophylaxis nowadays

Reye´s syndrome

Lesson III

Exanthematic diseases

Types of exanthems commonly, pathogenesis

Exanthematic diseases of bacterial and viral origin

Scarlet fever – epidemiology, pathogenesis, clinical course, diagnosis, therapy, and differential diagnosis

Toxic shock syndrome – history, epidemiology, pathogenesis, clinical course, diagnosis, therapy

Kawasaki syndrome – history, epidemiology, pathogenesis, clinical course, diagnosis, therapy

Rubella – epidemiology, pathogenesis, clinical course, diagnosis, differential diagnosis, complications, rubella in pregnancy, prophylaxis

Measles – epidemiology, pathogenesis, clinical course, diagnosis, complications, differential diagnosis, measles and immunity of organism, prophylaxis

Varicella (Chickenpox) – epidemiology, pathogenesis, clinical course, diagnosis, differential diagnosis, therapy, complications, varicella in pregnancy, varicella and immunodeficiency, prophylaxis

Herpes zoster – epidemiology, pathogenesis, clinical course, diagnosis, therapy

Megalerythema infectiosum – epidemiology, pathogenesis, clinical course, diagnosis, differential diagnosis, therapy, complications, megalerythema infectiosum in pregnancy

Exanthema subitum (Roseola infantum)– epidemiology, pathogenesis, clinical course, diagnosis, therapy, complications

Lesson IV

Lymphadenopathy

Occurrence of lymphadenopathy commonly, quick diagnosis is necessary

Viral causes of lymphadenopathy:

Adenovirus – epidemiology, clinical course, diagnosis, therapy

Infectious mononucleosis /virus Epstein-Barr, cytomegalovirus/ - epidemiology, pathogenesis, clinical course, diagnosis, therapy, complications

Parotitis epidemica (Mumps) – epidemiology, pathogenesis, clinical course, therapy, complications, therapy if complications, prophylaxis

Rubella, measles – clinical course exanthematic diseases

Gingivostomatitis herpetica (Aphthous stomatitis) – epidemiology, pathogenesis, clinical course, therapy, differential diagnosis

Bacterial cases of lymphadenopathy:

Infections of streptococci – angina, lymphadenopathy – epidemiology, pathogenesis, clinical course, diagnosis, therapy, complications

Infections of staphylococci – angina, lymphadenopathy, bacterial parotitis – epidemiology, pathogenesis, clinical course, diagnosis, therapy, complications

Tularaemia – history, epidemiology, pathogenesis, clinical course, types of tularaemia, diagnosis, therapy, complications

Diphtheria – epidemiology, pathogenesis, clinical course, diagnosis, therapy, complications, prophylaxis

Listeriosis – epidemiology, pathogenesis, clinical course, diagnosis, therapy, listeriosis in immunodeficiency

Yersiniosis – epidemiology, pathogenesis, clinical course, diagnosis, therapy

Parasitic cause of lymphadenopathy:

Toxoplasmosis – history, epidemiology, pathogenesis, clinical cause, diagnosis, therapy, toxoplasmosis in pregnancy, toxoplasmosis in immunodeficiency

Lesson V

Parasitic diseases

Malaria – history, epidemiology, pathogenesis, occurrence of malaria in the world, prophylaxis

Types of malaria, clinical course, diagnosis, therapy, complications

Amoebosis, giardiosis, echinococcosis, teniarhynchosis, hymenolepiosis, trichinosis (trichinellosis), ankylostomosis, askaridosis, enterobiosis, toxocarosis – etiology, epidemiology, clinical course, diagnosis, therapy, prophylaxis

Lesson VI

Infections of the nervous system – bacterial meningitis

Epidemiology. Ethiology. Clinical features. Diagnostic approach. Laboratory investigations, CSF features, serological tests, CT, MRI. Differential diagnosis. Treatment. Prognosis. Prevention

Acute meningitis – pyogenic: haemophilus meningitis, pneumococcal meningitis, meningococcal infection. Neonatal meningitis

Posttraumatic meningitis

Complications of meningitis. Brain abscess

Listeriosis and Listeria meningitis

Tuberculous meningitis

Fungal and parasitic infections of CNS (Cryptococcal meningitis, Toxoplasmosis)

Septicaemia. Septic shock

Lesson VII

Infections of the nervous system – aseptic meningitis

Viral meningitis and encephalitis /HSV1, 2, VZ, EBV, CMV, AD, PA, enteroviral, TBE

Postinfective and postvaccination encephalitis

Parotitis epidemica (Mumps) and complications (CNS). Encephalitis herpetica

Poliomyelitis and other enteroviral infections. Polio-like illness. Guillain - Barre syndrome

Polyneuritis

Tick borne infections /TBE, Lyme disease (borreliosis), ehrlichiosis, rickettsiosis, tularaemia/

Leptospirosis

Slow viral infections of the CNS (spongiform encephalopathies)

Rabies. Wound septicaemia (P. multocida)

Botulism

Tetanus

Lesson VIII

Respiratory tract infections

Herpesvirus infections (HSV-1, HSV-2), Chickenpox and herpes zoster

Influenza, parainfluenza, other viral infections of respiratory tract: RS virus, adenovirus, enterovirus, rhinovirus, acute obstructive laryngitis /croup/

Mycoplasmal and chlamydial infections /psittacosis, ornithosis/

Bacterial respiratory tract infections (Haemophilus influenzae infections, Pertussis and whooping cough syndrome). Actinomycosis

Anaerobic infections

Lesson IX

AIDS

AIDS as a consequence of HIV infection

History, epidemiology, pathogenesis, clinical pictures of various stages of HIV/AIDS, opportunistic infections and tumours associated with AIDS, laboratory and serological diagnosis, differential diagnosis, complications, advances in the treatment of HIV-infection (cART, HAART), vaccines, HIV and society.

Fungal infections. New herpetic viruses. Infections in immunocompromised people. Opportunistic infections

Literature recommended for students:

Mandal, B.K., Wilkins, E.G.L., Dunbar, E.M.,Mayon-White,R.T.: Infections Diseas