Classes
Publications
- Toxicological Sciences Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage2024 | Faculty of Medicine in Hradec Králové, Faculty of Pharmacy in Hradec Králové
- Cardiac miRNA expression during the development of chronic anthracycline-induced cardiomyopathy using an experimental rabbit model2024 | Faculty of Medicine in Hradec Králové
- Hypertension Research Characterization of a new model of chemotherapy-induced heart failure with reduced ejection fraction and nephrotic syndrome in Ren-2 transgenic rats2024 | Faculty of Medicine in Hradec Králové
- Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up2022 | Faculty of Medicine in Hradec Králové, Faculty of Pharmacy in Hradec Králové
- Development of a Rat Model of Intra-Amniotic Inflammation via Ultrasound-Guided Administration of a Triggering Agent in the Gestational Sac to Enable Analysis of Individual Amniotic Fluid Samples2022 | Faculty of Medicine in Hradec Králové, Faculty of Pharmacy in Hradec Králové
- Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase II beta Interactions2021 | Faculty of Medicine in Hradec Králové, Faculty of Pharmacy in Hradec Králové
- Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo2021 | Faculty of Medicine in Hradec Králové, Faculty of Pharmacy in Hradec Králové
- Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation2021 | Faculty of Medicine in Hradec Králové, Faculty of Pharmacy in Hradec Králové
- Development of water-soluble prodrugs of the bisdioxopiperazine topoisomerase II beta inhibitor ICRF-193 as potential cardioprotective agents against anthracycline cardiotoxicity2021 | Faculty of Medicine in Hradec Králové, Faculty of Pharmacy in Hradec Králové
- Investigation of Structure-Activity Relationships of Dexrazoxane Analogs Reveals Topoisomerase II beta Interaction as a Prerequisite for Effective Protection against Anthracycline Cardiotoxicity2020 | Faculty of Medicine in Hradec Králové, Faculty of Pharmacy in Hradec Králové
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