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13-hydroxyellipticine
Person
Class
Person
Publication
Programmes
Mgr. Radek Indra Ph.D.
Academic staff at Faculty of Science
3 classes
26 publications
Classes
class
Biochemistry
MC250P03B |
Faculty of Science
class
Molecular oncology
MC250P63 |
Faculty of Science
class
Biochemistry for IES
MO550P88 |
Faculty of Science
Publications
publication
Cytochrome b(5) plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine
2017 |
Faculty of Science, Second Faculty of Medicine
publication
Cytochrome b(5) Increases Cytochrome P450 3A4-Mediated Activation of Anticancer Drug Ellipticine to 13-Hydroxyellipticine Whose Covalent Binding to DNA Is Elevated by Sulfotransferases and N,O-Acetyltransferases
2012 |
Faculty of Science, Second Faculty of Medicine
publication
The impact of individual human cytochrome P450 enzymes on oxidative metabolism of anticancer drug lenvatinib
2022 |
Faculty of Science
publication
Apoferritin/vandetanib association is long-term stable but does not improve pharmacological properties of vandetanib
2021 |
Faculty of Science, Second Faculty of Medicine
publication
Benzo[a]pyrene-Induced Genotoxicity in Rats Is Affected by Co-Exposure to Sudan I by Altering the Expression of Biotransformation Enzymes
2021 |
Faculty of Science
publication
Cytochrome P450 and flavin-containing monooxygenase enzymes are responsible for differential oxidation of the anti-thyroid-cancer drug vandetanib by human and rat hepatic microsomal systems
2020 |
Faculty of Science, Second Faculty of Medicine
publication
Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b(5) Activity
2020 |
Faculty of Science
publication
Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells
2019 |
Faculty of Science, Second Faculty of Medicine
publication
Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation
2019 |
Faculty of Science, Second Faculty of Medicine
publication
Neutralization of lenvatinib charge hampers encapsulation into ferritin nanocages
2019 |
Faculty of Science, Faculty of Mathematics and Physics
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