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Endogenous ligands
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Mgr. Miroslav Kašpar
Academic staff at Faculty of Science
4 publications
Publications
publication
When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists
2023 |
Faculty of Science, Faculty of Pharmacy in Hradec Králové
publication
Selectivity of Oxidizing Agents toward Axial and Equatorial Hydroxyl Groups
2022 |
Faculty of Science, Central Library of Charles University
publication
(E)-7-Ethylidene-lithocholic Acid (7-ELCA) Is a Potent Dual Farnesoid X Receptor (FXR) Antagonist and GPBAR1 Agonist Inhibiting FXR-Induced Gene Expression in Hepatocytes and Stimulating Glucagon-like Peptide-1 Secretion From Enteroendocrine Cells
2021 |
Faculty of Science, Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
publication
3 beta-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3 alpha-epimer by hepatic metabolism
2020 |
Faculty of Science, Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
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