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PharmDr. Lukáš Hroch Ph.D.
Externí osoba na 1. lékařská fakulta
15 publikací
Publikace
publication
Benzothiazolyl ureas are low micromolar and uncompetitive inhibitors of 17β-HSD10 with implications to Alzheimer's disease treatment
2020 |
Publikace bez příslušnosti k fakultě
publication
Mitochondriální enzym ABAD a jeho role v rozvoji a léčbě Alzheimerovy nemoci
2020 |
Publikace bez příslušnosti k fakultě
publication
Novel benzothiazole-based ureas as 17 beta-HSD10 inhibitors, a potential Alzheimer's disease treatment
2019 |
Publikace bez příslušnosti k fakultě
publication
1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders
2018 |
1. lékařská fakulta
publication
Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment
2017 |
Publikace bez příslušnosti k fakultě
publication
6-Benzothiazolyl ureas, thioureas and guanidines are potent inhibitors of ABAD/17 beta-HSD10 and potential drugs for Alzheimer's disease treatment: Design, synthesis and in vitro evaluation
2017 |
Publikace bez příslušnosti k fakultě
publication
Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17 beta-HSD10 modulators for Alzheimer's disease treatment
2016 |
Publikace bez příslušnosti k fakultě
publication
Benzothiazoles - scaffold of interest for CNS targeted drugs
2015 |
Farmaceutická fakulta v Hradci Králové
publication
A Direct Interaction Between Mitochondrial Proteins and Amyloid-beta Peptide and its Significance for the Progression and Treatment of Alzheimer's Disease
2015 |
Publikace bez příslušnosti k fakultě
publication
Development of submicromolar 17 beta-HSD10 inhibitors and their in vitro and in vivo evaluation
2023 |
1. lékařská fakulta
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