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mutant
Person
Class
Person
Publication
Programmes
prof. RNDr. Jan Konvalinka CSc.
Academic staff at Faculty of Science
5 classes
164 publications
Classes
class
Molecular biology and genetics II
+1
MC250P16 |
Faculty of Science
class
Molecular Biology and Genetics II
MC250P16N |
Faculty of Science
class
Proteolysis and regulation of biological processes
MC250P39 |
Faculty of Science
class
Drug design and development
MC250P71 |
Faculty of Science
Publications
publication
Novel Substrate-Based Inhibitors of Human Glutamate Carboxypeptidase II with Enhanced Lipophilicity
2011 |
Faculty of Science, Central Library of Charles University
publication
Random mutagenesis of human serine racemase reveals residues important for the enzymatic activity
2010 |
Faculty of Science, First Faculty of Medicine, Faculty of Mathematics and Physics
publication
Ninety-nine is not enough: Molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region
2008 |
Faculty of Science
publication
Ninety Nine is Not Enough: Molecular Characterization of Inhibitor Resistant HIV-1 Protease Mutants with Insertions in the Flap Region.
2008 |
Faculty of Science
publication
Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir.
2008 |
Faculty of Science
publication
Molecular analysis of the HIV-1 resistance development: enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants
2007 |
Faculty of Science
publication
Non-infectious fluorimetric assay for phenotyping of drug-resistant HIV proteinase mutants
2006 |
Faculty of Science
publication
HIV-1 protease mutations and inhibitor modifications monitored on a series of complexes. Structural basis for the effect of the A71V mutation on the active site
2006 |
Faculty of Science
publication
Characterisation of mutated proteinases derived from HIV-positive patients: Enzyme activity, vitality and inhibition
2004 |
Faculty of Science
publication
An ethylenamine inhibitor binds tightly to both wild type and mutant HIV-1 proteases. Structure and energy study.
2003 |
Faculty of Science
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