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reductases
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Person
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doc. RNDr. Jakub Hofman Ph.D.
Academic staff at Faculty of Pharmacy in Hradec Králové
3 classes
37 publications
Classes
class
Current Strategies in Pharmacotherapy
GAF360 |
Faculty of Pharmacy in Hradec Králové
class
Current strategies in pharmacotherapy
+1
GAPS016 |
Faculty of Pharmacy in Hradec Králové
Publications
publication
Bruton's Tyrosine Kinase Inhibitor Zanubrutinib Effectively Modulates Cancer Resistance by Inhibiting Anthracycline Metabolism and Efflux
2022 |
Faculty of Pharmacy in Hradec Králové
publication
Isocitrate dehydrogenase 2 inhibitor enasidenib synergizes daunorubicin cytotoxicity by targeting aldo-keto reductase 1C3 and ATP-binding cassette transporters
2022 |
Faculty of Pharmacy in Hradec Králové
publication
Olaparib Synergizes the Anticancer Activity of Daunorubicin via Interaction with AKR1C3
2020 |
Faculty of Pharmacy in Hradec Králové
publication
Interactions of antileukemic drugs with daunorubicin reductases: could reductases affect the clinical efficacy of daunorubicin chemoregimens?
2020 |
Faculty of Pharmacy in Hradec Králové
publication
Cyclin-dependent kinase inhibitors AZD5438 and R547 show potential for enhancing efficacy of daunorubicin-based anticancer therapy: Interaction with carbonyl-reducing enzymes and ABC transporters
2019 |
Faculty of Pharmacy in Hradec Králové
publication
Buparlisib is a novel inhibitor of daunorubicin reduction mediated by aldo-keto reductase 1C3
2019 |
Faculty of Pharmacy in Hradec Králové
publication
Aldo-keto reductase 1C3 (AKR1C3): a missing piece of the puzzle in the dinaciclib interaction profile
2018 |
Faculty of Pharmacy in Hradec Králové
publication
Roscovitine and purvalanol A effectively reverse anthracycline resistance mediated by the activity of aldo-keto reductase 1C3 (AKR1C3): A promising therapeutic target for cancer treatment
2018 |
Faculty of Pharmacy in Hradec Králové
publication
Inhibition of human anthracycline reductases by emodin - A possible remedy for anthracycline resistance
2016 |
Faculty of Pharmacy in Hradec Králové
publication
Pharmacokinetic interactions of breast cancer chemotherapeutics with human doxorubicin reductases
2015 |
Faculty of Pharmacy in Hradec Králové
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